Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs

被引：2

作者：

Pabon, Adriana ^{[1
]}

Deharo, Eric ^{[2
,3
]}

Blair, Silvia ^{[1
]}

机构：

[1] Univ Antioquia, Grp Malaria, Medellin, Colombia

[2] Univ Toulouse, UPS, UMR 152, Lab Pharmacochim Subst Nat & Pharmacophores Redox, F-31062 Toulouse 9, France

[3] IRD, UMR 152, Lima, Peru

来源：

EXPERIMENTAL PARASITOLOGY | 2011年 / 127卷 / 01期

关键词：

Antimalarial; Solanum nudum; Drug interaction; Steroid; SUSCEPTIBILITY; ERYTHROCYTES; SOLANACEAE; PARASITES; COLOMBIA; CULTURE;

D O I：

10.1016/j.exppara.2010.08.009

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The effect of 16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione (SN-1) isolated from Solanum nudum Dunal (a Solanaceae traditionally used for treating fever in Colombia) on Plasmodium falciparum erythrocyte stages and its in vitro antiplasmodial activity when combined with the following conventional drugs was studied: chloroquine (CQ), amodiaquine (AQ), desethylamodiaquine (desethyl-AQ), quinine (QN), artemisinin (AR), atovaquone (ATV) and quinine (QN). It was found that SN-1 targeted trophozoites and had a synergistic effect when combined with CQ and QN; however, it had an antagonist effect when used with the other combinations. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：222 / 227

页数：6

共 8 条

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