The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia

被引：44

作者：

La Nasa, Giorgio

Littera, Roberto

Locatelli, Franco

Lai, Sara

Alba, Francesco

Caocci, Giovanni

Lisini, Daniela

Nesci, Sonia

Vacca, Adriana

Piras, Eugenia

Bernardo, Maria Ester

Cesare-Merlone, Alessandra Di

Orru, Sandro

Carcassi, Carlo

机构：

[1] Univ Cagliari, Cattedra Genet Med, Osped R Binaghi, Dipartimento Sci Med Internist, I-09126 Cagliari, Italy

[2] Univ Cagliari, Dipartimento Sci Mediche Internistiche, Osped R Binaghi, Ctr Trapianti Midollo Osseo,Cattedra Ematol, Cagliari, Italy

[3] Osped R Binaghi, Ctr Res Trapianti, Cagliari, Italy

[4] Univ Pavia, Policlin San Matteo, Fonaz IRCCS, I-27100 Pavia, Italy

[5] Osped S Salvatore, Ctr Trapianti Midollo Osseo Muraglia, Unita Operat Ematol, Pesaro, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 139卷 / 02期

关键词：

human leucocyte antigen-G; 14-basepair polymorphism; acute graft-versus-host disease; thalassaemia; bone marrow transplantation;

D O I：

10.1111/j.1365-2141.2007.06779.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.

引用

页码：284 / 288

页数：5

共 16 条

[1] Graft rejection after unrelated donor hematopoietic stera cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction [J].

Fleischhauer, K ;

Locatelli, F ;

Zecca, M ;

Orofino, MG ;

Giardini, C ;

de Stefano, P ;

Pession, A ;

Iannone, AM ;

Carcassi, C ;

Zino, E ;

La Nasa, G .

BLOOD, 2006, 107 (07) :2984-2992

[2] CLONING AND PHYSICAL MAPPING OF THE HLA CLASS-I REGION SPANNING THE HLA-E-TO-HLA-F INTERVAL BY USING YEAST ARTIFICIAL CHROMOSOMES [J].

GERAGHTY, DE ;

PEI, J ;

LIPSKY, B ;

HANSEN, JA ;

TAILLONMILLER, P ;

BRONSON, SK ;

CHAPLIN, DD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2669-2673

[3]

Gooley TA, 1999, STAT MED, V18, P695, DOI 10.1002/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.3.CO

[4]

2-F

[5] 14 BP DELETION POLYMORPHISM IN THE HLA-G GENE [J].

HARRISON, GA ;

HUMPHREY, KE ;

JAKOBSEN, IB ;

COOPER, DW .

HUMAN MOLECULAR GENETICS, 1993, 2 (12) :2200-2200

[6] NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS [J].

KAPLAN, EL ;

MEIER, P .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) :457-481

[7] Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part I: Unadjusted analysis [J].

Klein, JP ;

Rizzo, JD ;

Zhang, MJ ;

Keiding, N .

BONE MARROW TRANSPLANTATION, 2001, 28 (10) :909-915

[8] Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part 2: Regression modeling [J].

Klein, JP ;

Rizzo, JD ;

Zhang, MJ ;

Keiding, N .

BONE MARROW TRANSPLANTATION, 2001, 28 (11) :1001-1011

[9] Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions:: in vivo implications in transplanted patients [J].

Le Rond, S ;

Le Maoult, J ;

Créput, C ;

Menier, C ;

Deschamps, M ;

Le Friec, G ;

Amiot, L ;

Durrbach, A ;

Dausset, J ;

Carosella, ED ;

Rouas-Freiss, N .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (03) :649-660

[10] Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/regulatory T cells [J].

Le Rond, Solene ;

Azema, Christine ;

Krawice-Radanne, Irene ;

Durrbach, Antoine ;

Guettier, Catherine ;

Carosella, Edgardo D. ;

Rouas-Freiss, Nathalie .

JOURNAL OF IMMUNOLOGY, 2006, 176 (05) :3266-3276

← 1 2 →