The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia

被引：44
作者：
La Nasa, Giorgio
Littera, Roberto
Locatelli, Franco
Lai, Sara
Alba, Francesco
Caocci, Giovanni
Lisini, Daniela
Nesci, Sonia
Vacca, Adriana
Piras, Eugenia
Bernardo, Maria Ester
Cesare-Merlone, Alessandra Di
Orru, Sandro
Carcassi, Carlo
机构：
[1] Univ Cagliari, Cattedra Genet Med, Osped R Binaghi, Dipartimento Sci Med Internist, I-09126 Cagliari, Italy
[2] Univ Cagliari, Dipartimento Sci Mediche Internistiche, Osped R Binaghi, Ctr Trapianti Midollo Osseo,Cattedra Ematol, Cagliari, Italy
[3] Osped R Binaghi, Ctr Res Trapianti, Cagliari, Italy
[4] Univ Pavia, Policlin San Matteo, Fonaz IRCCS, I-27100 Pavia, Italy
[5] Osped S Salvatore, Ctr Trapianti Midollo Osseo Muraglia, Unita Operat Ematol, Pesaro, Italy
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 139卷 / 02期
关键词：
human leucocyte antigen-G; 14-basepair polymorphism; acute graft-versus-host disease; thalassaemia; bone marrow transplantation;
D O I：
10.1111/j.1365-2141.2007.06779.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.
引用
收藏
页码：284 / 288
页数：5
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