Mild Synthesis of mono-, bis- and tris 1,2-Dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine Derivatives Using Alkyl Disulfamic Acid Functionalized Magnetic Nanoparticles

被引：24

作者：

Bodaghifard, Mohammad A. ^{[1
]}

Faraki, Zahra ^{[1
]}

Karimi, Ali R. ^{[1
]}

机构：

[1] Arak Univ, Fac Sci, Dept Chem, POB 38156-88349, Arak, Iran

来源：

CURRENT ORGANIC CHEMISTRY | 2016年 / 20卷 / 15期

关键词：

Nanoparticles; magnetite; heterogeneous catalysis; sulfamic acid; imidazo[1,2-a]pyrimidine; multicomponent reaction; SOLVENT-FREE SYNTHESIS; MULTICOMPONENT REACTIONS; SEPARABLE CATALYST; EFFICIENT; 2-AMINOBENZIMIDAZOLE; ALDEHYDE;

D O I：

10.2174/1385272820666160218233729

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl disulfamic acid-functionalized silica-coated magnetic nanoparticles (ADSA-MNPs) have been synthesized as a hybrid organic-inorganic acidic nanoparticles and its catalytic activity has been evaluated in the synthesis of mono-, bis- and tris 1,2-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine via a one-pot three, pseudo-five or pseudo-seven component condensation reaction of aromatic aldehydes, malononitrile and 2-aminobezimidazole under solvent-free heating. The heterogeneous catalyst was facilely separated from the reaction mixture by utilizing external magnetic field and reused for several times without considerable decrease of catalytic performance.

引用

页码：1648 / 1654

页数：7