Residence Time Distribution of a Capillary Microreactor Used for Pharmaceutical Synthesis

被引：23

作者：

Siguemoto, Erica S. ^{[1
]}

Leite Reche, Leandro ^{[2
]}

Gut, Jorge A. W. ^{[1
,3
]}

Palma, Mauri S. A. ^{[2
]}

机构：

[1] Univ Sao Paulo, Dept Chem Engn, Ave Prof Luciano Gualberto 380, BR-05508010 Sao Paulo, Brazil

[2] Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo, Brazil

[3] Univ Sao Paulo, FoRC Food Res Ctr, Rua Lago 250, BR-05508080 Sao Paulo, Brazil

来源：

CHEMICAL ENGINEERING & TECHNOLOGY | 2020年 / 43卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

Axial dispersion; Microreactors; Plug flow; Process intensification; Residence time distribution; TUBE;

D O I：

10.1002/ceat.201900478

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The main drivers for application of small-scale reactors in the pharmaceutical industry are the possibility of rapid synthesis and screening of novel drugs as well as the readiness of the scale-up. The characterization of fluid flow pattern was performed through step-up and step-down residence time distribution experiments using a tracer at six different flow rates. Four single-parameter models were considered for representing deviations from ideal plug flow and ideal laminar flow in tubes. The model that provided the best results was the axial dispersion model and the Peclet and Reynolds numbers could be well correlated. Obtained Peclet values from 44 to 244 were close to Pe > 100, in which axial dispersion can be neglected and the reactor can be considered as plug flow reactor.

引用

页码：429 / 435

页数：7