Hepatitis B virus reactivation after effective sofosbuvir and ribavirin treatment in a patient with occult hepatitis B virus infection

被引：0

作者：

Odolini, Silvia ^{[1
,2
]}

Lanza, Paola ^{[1
,2
]}

Spinetti, Angiola ^{[1
,2
]}

Zaltron, Serena ^{[1
,2
]}

Urbinati, Lucia ^{[1
,2
]}

Vavassori, Andrea ^{[1
,2
]}

Nasta, Paola ^{[1
,2
]}

Festa, Elena ^{[1
,2
]}

Gargiulo, Franco ^{[3
]}

Rodella, Anna ^{[3
]}

Caruso, Arnaldo ^{[3
]}

Casari, Salvatore ^{[1
,2
]}

Castelli, Francesco ^{[1
,2
]}

Vigano, Mauro ^{[4
]}

机构：

[1] Univ Brescia, Clin Infect & Trop Dis, Brescia, Italy

[2] Spedali Civil Brescia, Gen Hosp, Brescia, Italy

[3] Brescia Spedali Civili, Lab Microbiol, Gen Hosp, Brescia, Italy

[4] Univ Milan, Hepatol Unit, Osped San Giuseppe, Milan, Italy

来源：

NEW MICROBIOLOGICA | 2017年 / 40卷 / 03期

关键词：

Reactivation; DAAs; HCV; Occult B hepatitis; C-VIRUS; COINFECTION; THERAPY;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Reactivation of the hepatitis B virus (HBV) has been reported in patients with occult infection (OBI), i. e. HBV surface antigen (HBsAg) negative, HBV core antibody (anti-HBc) positive +/- antibodies against HBsAg (anti-HBs) and detectable HBV DNA in serum or liver, receiving immunosuppressive or cytotoxic therapies. Recently, concerns have been raised regarding the risk of HBV reactivation in OBI patients treated with direct acting antiviral agents (DAAs) for chronic hepatitis C (CHC). Here we describe a case of HBV reactivation in a 72-year-old woman with OBI as a possible consequence of effective treatment with sofosbuvir (SOF) and ribavirin (Rbv) for genotype 2a/2c CHC.

引用

页码：218 / 220

页数：3

共 21 条

[1]

[Anonymous], 2017, J HEPATOL, V66, P153, DOI DOI 10.1016/j.jhep.2016.09.001

[2] Evaluation of Hepatitis B Reactivation Among 62,920 Veterans Treated With Oral Hepatitis C Antivirals [J].

Belperio, Pamela S. ;

Shahoumian, Troy A. ;

Mole, Larry A. ;

Backus, Lisa I. .

HEPATOLOGY, 2017, 66 (01) :27-36

[3] Hepatitis B Reactivation in Hepatitis B and C Coinfected Patients Treated With Antiviral Agents: A Systematic Review and Meta-analysis [J].

Chen, Guofeng ;

Wang, Cheng ;

Chen, Jing ;

Ji, Dong ;

Wang, Yudong ;

Wu, Vanessa ;

Karlberg, Johan ;

Lau, George .

HEPATOLOGY, 2017, 66 (01) :13-26

[4] Hepatitis B virus/hepatitis C virus coinfection: Epidemiology, clinical features, viral interactions and treatment [J].

Chu, Chi-Jen ;

Lee, Shou-Dong .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2008, 23 (04) :512-520

[5]

Chuang WL, 2005, ANTIVIR THER, V10, P125

[6] Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus [J].

Chung, Raymond T. ;

Davis, Gary L. ;

Jensen, Donald M. ;

Masur, Henry ;

Saag, Michael S. ;

Thomas, David L. ;

Aronsohn, Andrew I. ;

Charlton, Michael R. ;

Feld, Jordan J. ;

Fontana, Robert J. ;

Ghany, Marc G. ;

Godofsky, Eliot W. ;

Graham, Camilla S. ;

Kim, Arthur Y. ;

Kiser, Jennifer J. ;

Kottilil, Shyam ;

Marks, Kristen M. ;

Martin, Paul ;

Mitruka, Kiren ;

Morgan, Timothy R. ;

Naggie, Susanna ;

Raymond, Daniel ;

Reau, Nancy S. ;

Schooley, Robert T. ;

Sherman, Kenneth E. ;

Sulkowski, Mark S. ;

Vargas, Hugo E. ;

Ward, John W. ;

Wyles, David L. .

HEPATOLOGY, 2015, 62 (03) :932-954

[7] Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir [J].

Collins, Jeffrey M. ;

Raphael, Kara Loren ;

Terry, Charles ;

Cartwright, Emily J. ;

Pillai, Anjana ;

Anania, Frank A. ;

Farley, Monica M. .

CLINICAL INFECTIOUS DISEASES, 2015, 61 (08) :1304-1306

[8] Direct-acting antiviral treatment in adults infected with hepatitis C virus: Reactivation of hepatitis B virus coinfection as a further challenge [J].

De Monte, Anne ;

Courjon, Johan ;

Anty, Rodolphe ;

Cua, Eric ;

Naqvi, Alissa ;

Mondain, Veronique ;

Cottalorda, Jacqueline ;

Ollier, Laurence ;

Giordanengo, Valerie .

JOURNAL OF CLINICAL VIROLOGY, 2016, 78 :27-30

[9]

EMA, 2016, EMA REV DIRECT ACTIN

[10] Fulminant hepatitis B reactivation leading to liver transplantation in a patient with chronic hepatitis C treated with simeprevir and sofosbuvir: A case report [J].

Ende A.R. ;

Kim N.H. ;

Yeh M.M. ;

Harper J. ;

Landis C.S. .

Journal of Medical Case Reports, 9 (1)

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