NT-proBNP levels and mortality in a genera population-based cohort from Turkey: a long-term follow-up study

被引：2
|
作者：
Simsek, Mustafa Aytek [1 ]
Degertekin, Muzaffer [1 ]
Cabbar, Ayca Turer [1 ]
Aslanger, Emre [1 ]
Ozveren, Olcay [1 ]
Aydin, Sinan [2 ]
Mutlu, Bulent [3 ]
Erol, Cetin [4 ]
机构：
[1] Yeditepe Univ Hosp, Dept Cardiol, Istanbul, Turkey
[2] Fatih Sultan Mehmet Training & Res Hosp, Dept Cardiol, Istanbul, Turkey
[3] Marmara Univ Hosp, Dept Cardiol, Istanbul, Turkey
[4] Ankara Univ Hosp, Dept Cardiol, Istanbul, Turkey
来源：
BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 10期
关键词：
all-cause mortality; cardiovascular epidemiology; cardiovascular mortality; general population; NT-proBNP; BRAIN NATRIURETIC PEPTIDE; CARDIOVASCULAR EVENTS; HEART-FAILURE; BIOMARKERS; RISK; PREDICTORS; DEATH; MEN;
D O I：
10.2217/bmm-2018-0120
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: We investigated the relationship between NT-ProBNP and mortality in a general population-based cohort. Methods & Results: A total of 2021 out of 4650 participants from previously published HAPPY study were included. Mean follow-up was 84.5 +/- 10.4 months. After adjusting for risk factors, high levels of LogNT-proBNP predicted all-cause death (HR: 3.23; 95% CI: 2.20-4.75; p < 0.001) and cardiovascular death (HR: 3.85; 95% CI: 2.37-6.26; p < 0.001). Regression analysis revealed that LogNT-proBNP was an independent predictor of all-cause death (HR: 2.85; 95% CI: 1.91-4.24; p < 0.001) and cardiovascular death (HR: 3.02; 95% CI: 1.84-4.95; p < 0.001). Conclusion: Our study showed that in long term follow-up, NT-proBNP is associated with increased all-cause and cardiovascular mortality
引用
收藏
页码：1073 / 1081
页数：9
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