Characteristics and Predictors of Venous Thromboembolism Among Lymphoma Patients Undergoing Chemotherapy: A Cohort Study in China

被引:4
|
作者
Chen, Yue [1 ]
Lei, Haike [2 ]
Wang, Wei [1 ]
Zhu, Jie [1 ]
Zeng, Chensi [1 ]
Lu, Zhuo [1 ]
Li, Luchun [1 ]
Li, Dairong [1 ]
Long, Bo [1 ]
Liu, Haixia [1 ]
机构
[1] Chongqing Univ, Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis & I, Chongqing, Peoples R China
[2] Chongqing Univ, Canc Hosp, Chongqing Canc Multi Big Data Applicat Engn Res Ct, Chongqing, Peoples R China
关键词
VTE; lymphoma patients; chemotherapy; prospective cohort; targeted thromboprophylaxis; RISK-FACTORS; CANCER;
D O I
10.3389/fphar.2022.901887
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Venous thromboembolism (VTE) is a potential complication among lymphoma patients. We evaluated the incidence rate and predictors of VTE in lymphoma patients undergoing chemotherapy.Methods: The present study retrospectively studied 1,069 patients with lymphoma who were treated with chemotherapy from 2018 to 2020. We investigated clinical predictors of VTE among all patients. The follow-up results were obtained via telephone communication and from inpatient and outpatient records.Results: A total of 1,069 patients underwent chemotherapy for lymphoma. During a mean follow-up of 23.1 months, 52 (4.9%) patients developed VTE. According to a multivariate analysis, the five variables found to be independently associated with VTE were male sex (HR 2.273, 95% CI 1.197-4.316, p = 0.012), age >64-years-old (HR 2.256, 95% CI 1.017-5.005, p = 0.045), the number of cycles of chemotherapy (HR 4.579, 95% CI 1.173-17.883, p = 0.029), platelet count >= 350 x 10(9)/L (HR 2.533, 95% CI 1.187-5.406, p = 0.016), and D-dimer >0.5 mg/L (HR 4.367, 95% CI 2.124-8.981, p < 0.001).Conclusion: This population-based study confirms the risk factors for VTE among patients with lymphoma who underwent chemotherapy and confirms that targeted thromboprophylaxis may reduce the burden of VTE in this population.
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页数:7
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