Antidepressant-Like Effects of Fractions Prepared from Danzhi-Xiaoyao-San Decoction in Rats with Chronic Unpredictable Mild Stress: Effects on Hypothalamic-Pituitary-Adrenal Axis, Arginine Vasopressin, and Neurotransmitters

被引：23
作者：
Wu, Li-Li [1 ]
Liu, Yan [1 ]
Yan, Can [1 ]
Pan, Yi [1 ]
Su, Jun-Fang [2 ]
Wu, Wei-Kang [3 ]
机构：
[1] Guangzhou Univ Chinese Med, Sch Preclin Med, Dept Basic Theory Chinese Med, Higher Educ Mega Ctr, 232 Waihuandong Rd, Guangzhou 510060, Guangdong, Peoples R China
[2] Guangzhou Univ Chinese Med, Sch Preclin Med, Dept Pathophysiol, Higher Educ Mega Ctr, 232 Waihuandong Rd, Guangzhou 510060, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Sch Preclin Med, Dept Pathophysiol, 58 Zhongshan Er Rd, Guangzhou 510080, Guangdong, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2016年 / 2016卷
基金：
中国国家自然科学基金;
关键词：
TAIL SUSPENSION TEST; HPA-AXIS; DEPRESSION; SYSTEM; DOPAMINE; MICE; INVOLVEMENT; ANTAGONIST; GLUTAMATE; NEURONS;
D O I：
10.1155/2016/6784689
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The aim of the present study was to investigate the antidepressant-like effects of two fractions, including petroleum ether soluble fraction (Fraction A, FA) and water-EtOH soluble fraction (Fraction B, FB) prepared from the Danzhi-xiaoyao-san (DZXYS) by using chronic unpredictable mild stress-induced depressive rat model. The results indicated that DZXYS could ameliorate the depression-like behavior in chronic stress model of rats. The inhibition of hyperactivity of HPA axis and the modulation of monoamine and amino acid neurotransmitters in the hippocampus may be the important mechanisms underlying the action of DZXYS antidepressant-like effect in chronically stressed rats.
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页数：11
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