Ru(II)-Catalyzed Decarbonylative Alkylation and Annulations of Benzaldehydes with Iodonium Ylides under Chelation Assistance

被引：27

作者：

Li, Xiang ^{[1
]}

Shen, Yang ^{[1
]}

Zhang, Guodong ^{[2
]}

Zheng, Xin ^{[1
]}

Zhao, Qing ^{[1
]}

Song, Zihe ^{[1
]}

机构：

[1] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Shaanxi, Peoples R China

[2] Yangzhou Univ, Coll Chem & Chem Engn, 180 Siwangting Rd, Yangzhou 225002, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 29期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; DIVERGENT SYNTHESIS; INDOLE ALKALOIDS; FORMAL SYNTHESIS; SALICYLALDEHYDES; CONSTRUCTION; DIBENZOFURANS; ALDEHYDES; CHROMONES; ALKYNES;

D O I：

10.1021/acs.orglett.2c01843

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Ru(II)-catalyzed decarbonylative alkylation and annulation of salicylaldehydes and 2-aminobenzaldehydes with iodonium ylides has been developed for the synthesis of dibenzo[b,d]furans and NH-free carbazolones. The reaction proceeds smoothly under mild conditions with a low catalyst loading and a broad substrate compatibility. Notably, hydroxy and free amino groups were demonstrated to be the effective directing groups, enabling the successful aldehyde C-H bond activation and subsequent decarbonylation and annulation under the inexpensive Ru(II) catalyst.

引用

页码：5281 / 5286

页数：6

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