Rho GTPases: Promising candidates for overcoming chemotherapeutic resistance

被引:16
|
作者
Zheng, Chun-Wen [1 ,2 ]
Zeng, Rui-Jie [1 ,2 ]
Xu, Li-Yan [1 ,3 ]
Li, En-Min [1 ,2 ]
机构
[1] Shantou Univ, Dept Biochem & Mol Biol, Med Coll, Shantou 515041, Peoples R China
[2] Shantou Univ, Key Lab Mol Biol High Canc Incidence Coastal Chao, Med Coll, Shantou 515041, Peoples R China
[3] Shantou Univ, Inst Oncol Pathol, Med Coll, Shantou 515041, Peoples R China
关键词
Chemoresistance; Cell signaling; Targeted therapy; Inhibitor; Rac1; SMALL-MOLECULE INHIBITORS; CANCER CELL-MIGRATION; RATIONAL DESIGN; UP-REGULATION; CISPLATIN RESISTANCE; REDUCED EXPRESSION; INDUCED APOPTOSIS; STRUCTURAL BASIS; RAC GTPASE; ACTIVATION;
D O I
10.1016/j.canlet.2020.01.018
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Despite therapeutic advances, resistance to chemotherapy remains a major challenge to patients with malignancies. Rho GTPases are essential for the development and progression of various diseases including cancer, and a vast number of studies have linked Rho GTPases to chemoresistance. Therefore, understanding the underlying mechanisms can expound the effects of Rho GTPases towards chemotherapeutic agents, and targeting Rho GTPases is a promising strategy to downregulate the chemo-protective pathways and overcome chemoresistance. Importantly, exceptions in certain biological conditions and interactions among the members of Rho GTPases should be noted. In this review, we focus on the role of Rho GTPases, particularly Rac1, in regulating chemoresistance and provide an overview of their related mechanisms and available inhibitors, which may offer novel options for future targeted cancer therapy.
引用
收藏
页码:65 / 78
页数:14
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