Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function

被引：134

作者：

Gupte, Anisha A. ^{[1
]}

Pownall, Henry J. ^{[2
]}

Hamilton, Dale J. ^{[1
,3
]}

机构：

[1] Weill Cornell Med Coll, Houston Methodist Res Inst, Bioenerget Lab, Houston, TX 77030 USA

[2] Weill Cornell Med Coll, Houston Methodist Res Inst, Methodist DeBakey Heart & Vasc Inst, Atherosclerosis & Lipoprot Res, Houston, TX 77030 USA

[3] Weill Cornell Med Coll, Houston Methodist Dept Med, Houston, TX 77030 USA

来源：

JOURNAL OF DIABETES RESEARCH | 2015年 / 2015卷

基金：

美国国家卫生研究院;

关键词：

RECEPTOR-ALPHA; SKELETAL-MUSCLE; ADIPOSE-TISSUE; WOMENS HEALTH; ER-BETA; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; REPLACEMENT THERAPY; GLUCOSE-HOMEOSTASIS; HORMONE-THERAPY;

D O I：

10.1155/2015/916585

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action. The metabolic effects of estrogen are mediated primarily by its receptor, estrogen receptor-alpha; however, the detailed understanding of its mechanisms is incomplete. Recent investigations suggest that estrogen receptor-alpha elicits the metabolic effects of estrogen by genomic, nongenomic, and mitochondrial mechanisms that regulate insulin signaling, substrate oxidation, and energetics. This paper reviews clinical and experimental studies on the mechanisms of estrogen and the current state of knowledge regarding physiological and pathobiological influences of estrogen on metabolism.

引用

页数：9

共 77 条

[1] Tissue-Selective Estrogen Complexes A Promising Option for the Comprehensive Management of Menopausal Symptoms [J].

Archer, David F. .

DRUGS & AGING, 2010, 27 (07) :533-544

[2] Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract [J].

Barrera, Jose ;

Chambliss, Ken L. ;

Ahmed, Mohamed ;

Tanigaki, Keiji ;

Thompson, Bonne ;

McDonald, Jeffrey G. ;

Mineo, Chieko ;

Shaul, Philip W. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2014, 307 (03) :E345-E354

[3] Participation of ERα and ERβ in glucose homeostasis in skeletal muscle and white adipose tissue [J].

Barros, Rodrigo P. A. ;

Gabbi, Chiara ;

Morani, Andrea ;

Warner, Margaret ;

Gustafsson, Jan-Ake .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 297 (01) :E124-E133

[4] Muscle GLUT4 regulation by estrogen receptors ERβ and ERα [J].

Barros, RPA ;

Machado, UF ;

Warner, M ;

Gustafsson, JÅ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (05) :1605-1608

[5] A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury [J].

Bopassa, Jean Chrisostome ;

Eghbali, Mansoureh ;

Toro, Ligia ;

Stefani, Enrico .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2010, 298 (01) :H16-H23

[6] Direct antioxidant and protective effect of estradiol on isolated mitochondria [J].

Borras, Consuelo ;

Gambini, Juan ;

Lopez-Grueso, Raul ;

Pallardo, Federico V. ;

Vina, Jose .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (01) :205-211

[7] Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice:: insulin sensitivity in the liver [J].

Bryzgalova, G ;

Gao, H ;

Ahren, B ;

Zierath, JR ;

Galuska, D ;

Steiler, TL ;

Dahlman-Wright, K ;

Nilsson, S ;

Gustafsson, JÅ ;

Efendic, S ;

Khan, A .

DIABETOLOGIA, 2006, 49 (03) :588-597

[8] Estradiol stimulates mitochondrial biogenesis and adiponectin expression in skeletal muscle [J].

Capllonch-Amer, Gabriela ;

Sbert-Roig, Miquel ;

Galmes-Pascual, Bel M. ;

Proenza, Ana M. ;

Llado, Isabel ;

Gianotti, Magdalena ;

Garcia-Palmer, Francisco J. .

JOURNAL OF ENDOCRINOLOGY, 2014, 221 (03) :391-403

[9] The emergence of the metabolic syndrome with menopause [J].

Carr, MC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06) :2404-2411

[10] Role of estrogen on skeletal muscle mitochondrial function in ovariectomized rats: a time course study in different fiber types [J].

Cavalcanti-de-Albuquerque, J. P. A. ;

Salvador, I. C. ;

Martins, Eduarda Lopes ;

Jardim-Messeder, D. ;

Werneck-de-Castro, J. P. S. ;

Galina, A. ;

Carvalho, D. P. .

JOURNAL OF APPLIED PHYSIOLOGY, 2014, 116 (07) :779-789

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