Cross-Species Transmission of Swine Hepatitis E Virus Genotype 3 to Rabbits

被引:8
|
作者
Han, Sang-Hoon [1 ]
Park, Byung-Joo [1 ]
Ahn, Hee-Seop [1 ]
Kim, Yong-Hyun [1 ]
Go, Hyeon-Jeong [1 ]
Lee, Joong-Bok [1 ]
Park, Seung-Yong [1 ]
Song, Chang-Seon [1 ]
Lee, Sang-Won [1 ]
Choi, Yang-Kyu [2 ]
Choi, In-Soo [1 ]
机构
[1] Konkuk Univ, Coll Vet Med, Dept Infect Dis, 120 Neungdong Ro, Seoul 05029, South Korea
[2] Konkuk Univ, Coll Vet Med, Dept Lab Anim Med, 120 Neungdong Ro, Seoul 05029, South Korea
来源
VIRUSES-BASEL | 2020年 / 12卷 / 01期
关键词
HEV; rabbit; swine; antibody; RNA; transmission; inflammation; EXPERIMENTAL-INFECTION; FARMED RABBITS; PIGS; PATHOGENESIS; PREVALENCE; STRAIN; RISK; HEV;
D O I
10.3390/v12010053
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Hepatitis E virus (HEV) is a quasi-enveloped, positive-sense single stranded RNA virus. HEV continually expands the host ranges across animal species. In this study, the possibility of cross-species infection with swine HEV-3 was investigated using rabbits. A total of fourteen 8-week old, specific pathogen-free rabbits were divided into three experimental groups. Four rabbits were used as negative controls, four rabbits were infected with rabbit HEV as positive controls, and six rabbits were inoculated with swine HEV-3. HEV RNA were detected from serum and fecal samples after viral challenge. The levels of anti-HEV antibodies, pro-inflammatory cytokines (IL-1, IL-6, TNF-alpha and IFN-alpha), and liver enzymes (alanine and aspartate aminotransferases) were determined in serum samples. Histopathological lesions were examined in liver tissues. Viral RNA and anti-HEV antibodies were identified in rabbits inoculated with swine HEV-3 demonstrating positive infectivity of the virus. However, pro-inflammatory cytokine and liver enzyme levels in serum were not significantly elevated, and only mild inflammatory lesions were detected in the liver tissues of rabbits infected with swine HEV-3. These results suggest that swine HEV-3 can engage in cross-species transmission to rabbits, but causes only mild inflammation of the liver.
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页数:9
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