Deriving a management algorithm for emphysematous pyelonephritis: Can we rely on minimally invasive strategies or should we be opting for earlier nephrectomy?

被引:20
作者
Boakes, Eve [1 ]
Batura, Deepak [1 ]
机构
[1] London North West Healthcare NHS Trust, Dept Urol, London, England
关键词
Emphysematous; Pyelonephritis; Percutaneous nephrostomy; Kidney; Infection; Nephrectomy; PERCUTANEOUS DRAINAGE; SPECTRUM; EXPERIENCE;
D O I
10.1007/s11255-017-1706-8
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose To analyse the incidence and management of emphysematous pyelonephritis (EPN) in North West London and examine factors that influence immediate and 6-month outcomes with the aim of guiding future management. Methods This work analyses EPN cases from the London North West Healthcare NHS Trust from October 2006 to July 2015 (population ae 850,000). Diagnosis and stage were confirmed by computed tomography (CT). Demographic, clinical, biochemical and microbiological characteristics were assessed. Treatment modalities were medical management, minimally invasive management (MIM) and surgical. Immediate and 6-month outcomes were analysed. Results Thirteen cases were identified (f = 8, m = 5) from 5525 CT scans. EPN occurred in patients with diabetes mellitus (n = 11, 84.6%), hypertension (n = 10, 76.9%) or urinary tract calculi (n = 7, 53.85%). Unilateral EPN occurred predominantly (n = 11, 84.6%); 46.1% (n = 6) were class 1 or 2 and 53.8% (n = 7) class 3 or 4. Escherichia coli was most commonly cultured (n = 5, 38.46%). All patients received antibiotics, and ten cases required MIM. Two patients had a delayed nephrectomy, both survived. Mortality was 15.4% (n = 2, grade 1 and 3a), both died acutely post-MIM, neither underwent emergency nephrectomy. At 6 months, eight patients had ongoing renal impairment. No specific poor prognostic factors were identifiable. Conclusions Patients with low-grade EPN may also have a high mortality rate. In the two cases who died, earlier consideration for nephrectomy may have been prudent. It may be beneficial to have a low threshold for prompt emergency nephrectomy in severe cases and where MIM treatment has failed. We suggest a management algorithm to guide clinicians and minimise mortality.
引用
收藏
页码:2127 / 2136
页数:10
相关论文
共 22 条
[1]   Emphysematous pyelonephritis: Time for a management plan with an evidence-based approach [J].
Aboumarzouk, Omar M. ;
Hughes, Owen ;
Narahari, Krishna ;
Coulthard, Richard ;
Kynaston, Howard ;
Chlosta, Piotr ;
Somani, Bhaskar .
ARAB JOURNAL OF UROLOGY, 2014, 12 (02) :106-115
[2]   DEFINITIONS FOR SEPSIS AND ORGAN FAILURE AND GUIDELINES FOR THE USE OF INNOVATIVE THERAPIES IN SEPSIS [J].
BONE, RC ;
BALK, RA ;
CERRA, FB ;
DELLINGER, RP ;
FEIN, AM ;
KNAUS, WA ;
SCHEIN, RMH ;
SIBBALD, WJ .
CHEST, 1992, 101 (06) :1644-1655
[3]  
Chuang YW, 2007, CLIN NEPHROL, V68, P42
[4]   ESBLs: A Clear and Present Danger? [J].
Dhillon, Rishi H. -P. ;
Clark, John .
CRITICAL CARE RESEARCH AND PRACTICE, 2012, 2012
[5]   Emphysematous pyelonephritis -: Clinicoradiological classification, management, prognosis, and pathogenesis [J].
Huang, JJ ;
Tseng, CC .
ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (06) :797-805
[6]  
Kamaliah M. D., 2005, Southeast Asian Journal of Tropical Medicine and Public Health, V36, P725
[7]   Predictive factors for mortality and need for nephrectomy in patients with emphysematous pyelonephritis [J].
Kapoor, Rakesh ;
Muruganandham, Kaliyaperumal ;
Gulia, Anil Kumar ;
Singla, Manish ;
Agrawal, Saurabh ;
Mandhani, Anil ;
Ansari, M. S. ;
Srivastava, Aneesh .
BJU INTERNATIONAL, 2010, 105 (07) :986-989
[8]   Retrospective analysis of clinical profile prognostic factors and outcomes of 19 patients of emphysematous pyelonephritis [J].
Khaira, Ambar ;
Gupta, Ankur ;
Rana, Devendra S. ;
Gupta, Ashwini ;
Bhalla, Anil ;
Khullar, Dinesh .
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2009, 41 (04) :959-966
[9]   Recommended Initial Antimicrobial Therapy for Emphysematous Pyelonephritis: 51 Cases and 14-Year-Experience of a Tertiary Referral Center [J].
Lu, Yu-Chuan ;
Hong, Jian-Hua ;
Chiang, Bing-Juin ;
Pong, Yuan-Hung ;
Hsueh, Po-Ren ;
Huang, Chao-Yuan ;
Pu, Yeong-Shiau .
MEDICINE, 2016, 95 (21)
[10]   Nephroureterectomy for emphysematous pyelonephritis: An aggressive approach is sometimes necessary. A case report and literature review [J].
Nana, Gael R. ;
Brodie, Andrew ;
Akhter, Waseem ;
Karim, Omer ;
Motiwala, Hanif .
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 2015, 10 :179-182