Why is the SARS-CoV-2 Omicron variant milder?

被引：20
作者：
Xia, Bingqing [1 ,2 ]
Wang, Yi [1 ,3 ]
Pan, Xiaoyan [4 ]
Cheng, Xi [1 ,2 ]
Ji, Hongying [1 ]
Zuo, Xiaoli [1 ]
Jiang, Hualiang [1 ,2 ,5 ]
Li, Jia [1 ,2 ]
Gao, Zhaobing [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Stake Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
[2] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
[3] Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China
[4] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430071, Peoples R China
[5] Lingang Lab, Shanghai 201602, Peoples R China
来源：
INNOVATION | 2022年 / 3卷 / 04期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.xinn.2022.100251
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页数：2
相关论文
共 5 条
[1]   β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway [J].
Ghosh, Sourish ;
Dellibovi-Ragheb, Teegan A. ;
Kerviel, Adeline ;
Pak, Eowyn ;
Qiu, Qi ;
Fisher, Matthew ;
Takvorian, Peter M. ;
Bleck, Christopher ;
Hsu, Victor W. ;
Fehr, Anthony R. ;
Perlman, Stanley ;
Achar, Sooraj R. ;
Straus, Marco R. ;
Whittaker, Gary R. ;
de Haan, Cornelis A. M. ;
Kehrl, John ;
Altan-Bonnet, Gregoire ;
Altan-Bonnet, Nihal .
CELL, 2020, 183 (06) :1520-+
[2]   Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers [J].
Mandala, Venkata S. ;
McKay, Matthew J. ;
Shcherbakov, Alexander A. ;
Dregni, Aurelio J. ;
Kolocouris, Antonios ;
Hong, Mei .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020, 27 (12) :1202-U270
[3]   Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity [J].
Markov, Peter, V ;
Katzourakis, Aris ;
Stilianakis, Nikolaos, I .
NATURE REVIEWS MICROBIOLOGY, 2022, 20 (05) :251-252
[4]   Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron [J].
Shuai, Huiping ;
Chan, Jasper Fuk-Woo ;
Hu, Bingjie ;
Chai, Yue ;
Yuen, Terrence Tsz-Tai ;
Yin, Feifei ;
Huang, Xiner ;
Yoon, Chaemin ;
Jing-Chu Hu ;
Liu, Huan ;
Shi, Jialu ;
Liu, Yuanchen ;
Zhu, Tianrenzheng ;
Zhang, Jinjin ;
Hou, Yuxin ;
Wang, Yixin ;
Lu, Lu ;
Jian-Piao Cai ;
Zhang, Anna Jinxia ;
Zhou, Jie ;
Yuan, Shuofeng ;
Brindley, Melinda A. ;
Bao-Zhong Zhang ;
Jian-Dong Huang ;
To, Kelvin Kai-Wang ;
Kwok-Yung Yuen ;
Chu, Hin .
NATURE, 2022, 603 (7902) :693-+
[5]   SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target [J].
Xia, Bingqing ;
Shen, Xurui ;
He, Yang ;
Pan, Xiaoyan ;
Liu, Feng-Liang ;
Wang, Yi ;
Yang, Feipu ;
Fang, Sui ;
Wu, Yan ;
Duan, Zilei ;
Zuo, Xiaoli ;
Xie, Zhuqing ;
Jiang, Xiangrui ;
Xu, Ling ;
Chi, Hao ;
Li, Shuangqu ;
Meng, Qian ;
Zhou, Hu ;
Zhou, Yubo ;
Cheng, Xi ;
Xin, Xiaoming ;
Jin, Lin ;
Zhang, Hai-Lin ;
Yu, Dan-Dan ;
Li, Ming-Hua ;
Feng, Xiao-Li ;
Chen, Jiekai ;
Jiang, Hualiang ;
Xiao, Gengfu ;
Zheng, Yong-Tang ;
Zhang, Lei-Ke ;
Shen, Jingshan ;
Li, Jia ;
Gao, Zhaobing .
CELL RESEARCH, 2021, 31 (08) :847-860
1