CSE1L silencing impairs tumor progression via MET/STAT3/PD-L1 signaling in lung cancer

被引：4

作者：

Liu, Weijun ^{[1
]}

Zhou, Zhiqing ^{[2
]}

Li, Yu ^{[2
]}

Xu, Jiali ^{[2
]}

Shen, Yang ^{[2
]}

Luo, Suisui ^{[2
]}

Zhou, Yujie ^{[2
]}

Wu, Xing ^{[2
]}

Zhao, Huijie ^{[2
]}

Beer, David G. ^{[3
]}

He, Yanli ^{[4
]}

Chen, Guoan ^{[2
]}

机构：

[1] Kunming Univ Sci & Technol, Affiliated Hosp, Peoples Hosp Yunnan Prov 1, Dept Anorectal Dis, Kunming 650032, Yunnan, Peoples R China

[2] Southern Univ Sci & Technol, Sch Med, 1088 Xueyuan Ave, Shenzhen 518055, Guangzhou, Peoples R China

[3] Univ Michigan, Dept Surg, Med Sch, Ann Arbor, MI 48109 USA

[4] Guangzhou Univ Chinese Med, Sch Basic Med, Guangzhou 510006, Guangdong, Peoples R China

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2021年 / 11卷 / 09期

关键词：

Lung cancer; CSE1L; MET; STAT3; PD-L1; CELL-PROLIFERATION; EXPRESSION; GENE; APOPTOSIS; PROTEIN; METASTASIS; MIGRATION; SURVIVAL; INVASION; GROWTH;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CSE1L is involved in the cancer progression of several types of cancer. Its expression status, potential oncogenic role and underlying mechanism in lung cancer, however, are unclear. Here, we investigated CSE1L expression in primary lung adenocarcinoma based on multiple datasets and then investigated its oncologic role in lung cancer. We also examined the potential molecular mechanisms of CSE1L in cancer progression. CSE1L levels were increased in cancer as compared to normal lung tissues. CSE1L expression was higher in poorly-differentiated late stage and lymph node positive metastatic tumors. Higher CSE1L level was correlated with worse patient outcome. Knockdown of CSE1L using siRNAs impaired cell proliferation, invasion, migration and induced cell apoptosis. Mechanistically, MET, STAT3 and PD-L1 proteins were decreased upon CSE1L silencing. These results suggest that CSE1L may affect tumor progression through MET/STAT3/PD-L1 signaling. CSE1L may have potential as a biomarker and therapeutic target for lung cancer.

引用

页码：4380 / +

页数：17

共 59 条

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