Pharmacokinetic evaluation of ambrisentan

被引：15

作者：

Buckley, Mitchell S. ^{[2
]}

Wicks, Laura M. ^{[2
]}

Staib, Robin L. ^{[2
]}

Kirejczyk, Anna K. ^{[2
]}

Varker, Andrew S. ^{[2
]}

Gibson, Jamie J. ^{[3
,4
]}

Feldman, Jeremy P. ^{[1
]}

机构：

[1] Arizona Pulm Specialists Ltd, Phoenix, AZ 85012 USA

[2] Banner Good Samaritan Med Ctr, Dept Pharm, Phoenix, AZ 85006 USA

[3] St Josephs Hosp, Phoenix, AZ 85013 USA

[4] Med Ctr, Dept Pharm, Phoenix, AZ 85013 USA

来源：

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2011年 / 7卷 / 03期

关键词：

PULMONARY ARTERIAL-HYPERTENSION; ENDOTHELIN RECEPTOR ANTAGONISTS; BOSENTAN THERAPY; DOUBLE-BLIND; INHALED ILOPROST; OPEN-LABEL; COMBINATION; SILDENAFIL; SITAXSENTAN; MULTICENTER;

D O I：

10.1517/17425255.2011.557181

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Areas covered: This review focuses on, and critically appraises, the clinical efficacy and safety of ambrisentan as well as its pharmacokinetic and pharmacodynamic properties. The article also gives an expert perspective on the role of ambrisentan in the management of PAH. Expert opinion: Ambrisentan is an effective and safe treatment which is, in the authors' opinion, a valuable addition to the armamentarium against PAH. Ambrisentan offers a relative lack of drug interactions, once daily dosing and reassuring liver safety, offering safety and convenience advantages over bosentan. Presently, there is a lack of comparative studies between PDE5 inhibitors and endothelin receptor antagonists and a lack of data comparing bosentan with ambrisentan. This is hindering data-based conclusions regarding relative efficacy and further studies are needed to define the role of ambrisentan in the management of PAH.

引用

页码：371 / 380

页数：10

共 54 条

[31]

IVY DD, 2009, AM THOR SOC INT C SA

[32] Caring for the orphan's orphan: treatment of patients with portopulmonary hypertension [J].

Kawut, S. M. .

EUROPEAN RESPIRATORY JOURNAL, 2007, 30 (06) :1038-1040

[33] Quality of life in pulmonary arterial hypertension: Improvement and maintenance with bosentan [J].

Keogh, Anne M. ;

McNeil, Keith D. ;

Wlodarczyk, John ;

Gabbay, Eli ;

Williams, Trevor J. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2007, 26 (02) :181-187

[34] The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house? [J].

Kirkby, N. S. ;

Hadoke, P. W. F. ;

Bagnall, A. J. ;

Webb, D. J. .

BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 (06) :1105-1119

[35] Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension [J].

Langleben, David .

CLINICS IN CHEST MEDICINE, 2007, 28 (01) :117-+

[36] Ambrisentan Therapy in Patients With Pulmonary Arterial Hypertension Who Discontinued Bosentan or Sitaxsentan Due to Liver Function Test Abnormalities [J].

McGoon, Michael D. ;

Frost, Adaani E. ;

Oudiz, Ronald J. ;

Badesch, David B. ;

Galie, Nazzareno ;

Olschewski, Horst ;

McLaughlin, Vallerie V. ;

Gerber, Michael J. ;

Dufton, Chris ;

Despain, Darrin J. ;

Rubin, Lewis J. .

CHEST, 2009, 135 (01) :122-129

[37] Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension [J].

McLaughlin, Vallerie V. ;

Oucliz, Ronald J. ;

Frost, Aclaani ;

Tapson, Victor F. ;

Murali, Srinivas ;

Channick, Richard N. ;

Badesch, David B. ;

Barst, Robyn J. ;

Hsu, Henry H. ;

Rubin, Lewis J. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (11) :1257-1263

[38] Survival with first-line bosentan in patients with primary pulmonary hypertension [J].

McLaughlin, VV ;

Sitbon, O ;

Badesch, DB ;

Barst, RJ ;

Black, C ;

Gallè, N ;

Rainisio, M ;

Simonneau, G ;

Rubin, LJ .

EUROPEAN RESPIRATORY JOURNAL, 2005, 25 (02) :244-249

[39] Long-Term Ambrisentan Therapy for the Treatment of Pulmonary Arterial Hypertension [J].

Oudiz, Ronald J. ;

Galie, Nazzareno ;

Olschewski, Horst ;

Torres, Fernando ;

Frost, Adaani ;

Ghofrani, Hossein A. ;

Badesch, David B. ;

McGoon, Michael D. ;

McLaughlin, Vallerie V. ;

Roecker, Ellen B. ;

Harrison, Brooke C. ;

Despain, Darrin ;

Dufton, Christopher ;

Rubin, Lewis J. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (21) :1971-1981

[40]

*PFIZ CAN, 2008, THEL SIT PACK INS

← 1 2 3 4 5 6 →