Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine in coronary artery disease

被引：13
作者：
Gad, Mohamed Z. [1 ]
Hassanein, Sally I. [1 ]
Abdel-Maksoud, Sahar M. [1 ]
Shaban, Gamal M. [2 ]
Abou-Aisha, Khaled [1 ]
Elgabarty, Hossam A. [1 ]
机构：
[1] German Univ, Fac Pharm & Biotechnol, Cairo, Egypt
[2] Natl Heart Inst, Cairo, Egypt
来源：
BIOMARKERS | 2010年 / 15卷 / 08期
关键词：
ADMA; L-arginine; coronary artery disease; DDAH2 gene polymorphism; Egyptians; SDMA; NITRIC-OXIDE SYNTHASE; ENDOGENOUS INHIBITOR; DIMETHYLAMINOHYDROLASE; EXPRESSION; OLIGONUCLEOTIDES; LOCALIZATION; PLASMA; DDAH2; ADMA;
D O I：
10.3109/1354750X.2010.519784
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), L-arginine, and C-reactive protein (hsCRP) levels were assessed in 100 Egyptian male 35-50-year-old patients with coronary artery disease (CAD), classified into: patients under conservative medical treatment, patients directed for percutaneous coronary interventions, patients directed for coronary artery bypass graft operation and patients suffering from acute myocardial infarction. Age- and sex-matched controls (n = 100) were included. Correlation between serum levels of biomarkers and dimethylarginine dimethylaminohydrolase-2 (DDAH-2) genotypes was studied. No association between biomarkers and carriage of the specific DDAH2 SNP2 (-449C/G, rs805305) genotype was detected. Further studies are required to confirm the contribution of the biomarkers in the predisposition of CAD.
引用
收藏
页码：746 / 752
页数：7
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