Pestaloquinols A and B, Isoprenylated Epoxyquinols from Pestalotiopsis sp.

被引：39

作者：

Ding, Gang ^{[1
,2
]}

Zhang, Fan ^{[3
]}

Chen, Hong ^{[4
]}

Guo, Liangdong ^{[3
]}

Zou, Zhongmei ^{[1
,2
]}

Che, Yongsheng ^{[3
,5
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China

[4] Med Coll Chinese Peoples Armed Police Forces, Tianjin 300162, Peoples R China

[5] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 02期

关键词：

ENDOPHYTIC FUNGUS; ANTIANGIOGENIC ACTIVITY; OXIDATIVE DIMERIZATION; TORREYANIC ACID; REACTION MODES; AMBUIC ACID; PRECURSORS; METABOLITES; DERIVATIVES; REACTIVITY;

D O I：

10.1021/np100723t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new isoprenylated epoxyquinol derivatives, pestaloquinols A (2) and B (3), and their putative biosynthetic precursor, cytosporin D (1), were isolated from the crude extract of the plant endophytic fungus Pestalotiopsis sp. The structures of these compounds were elucidated primarily by NMR experiments. Pestaloquinols A (2) and B (3) possess a previously undescribed nonacyclic ring system and showed cytotoxicity against HeLa cells.

引用

页码：286 / 291

页数：6

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