The Feasibility of Plerixafor as a Second-line Stem Cell Mobilizing Agent in Children

被引：22
作者：
Aabideen, Kanakkande [1 ]
Anoop, Parameswaran [1 ]
Ethell, Mark E. [1 ]
Potter, Mike N. [1 ]
机构：
[1] Royal Marsden Hosp NHS Fdn Trust, Dept Pediat Hematooncol, Sutton, Surrey, England
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2011年 / 33卷 / 01期
关键词：
Stem cell mobilization; plerixafor; AMD3100; PLUS G-CSF; SUCCESSFUL MOBILIZATION; AMD3100; MEDULLOBLASTOMA; TRANSPLANT; EXPERIENCE; HARVEST;
D O I：
10.1097/MPH.0b013e3181e9e4c2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In patients heavily pretreated with myelosuppressive chemotherapy or irradiation, Granulocyte colony stimulating factor (G-CSF) may fail to mobilize stem cells from the bone marrow. Plerixafor is emerging as a reliable alternate option in such situations in adult patients. Robust data in support of the high efficacy and safety of plerixafor are available in adults. Very little evidence is available on the usefulness of this drug among children. We report our experience with plerixafor usage on 5 occasions in pediatric patients, with a success rate of 60%. No significant side effects were encountered in any patient.
引用
收藏
页码：65 / 67
页数：3
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