Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation

被引：119

作者：

Arce-Sillas, Asiel ^{[1
]}

Denisse Alvarez-Luquin, Diana ^{[1
]}

Tamaya-Dominguez, Beatriz ^{[1
]}

Gomez-Fuentes, Sandra ^{[1
]}

Trejo-Garcia, Abel ^{[1
]}

Melo-Salas, Marlene ^{[1
]}

Cardenas, Graciela ^{[1
]}

Rodriguez-Ramirez, Juan ^{[1
]}

Adalid-Peralta, Laura ^{[1
,2
]}

机构：

[1] Inst Nacl Neurol & Neurocirug, Mexico City 14269, DF, Mexico

[2] Inst Nacl Neurol & Neurocirug, Inst Invest Biomed, Unidad Perifer, Mexico City 14269, DF, Mexico

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2016年 / 2016卷

关键词：

GRANZYME-B; DENDRITIC CELLS; MEDIATED SUPPRESSION; INDOLEAMINE 2,3-DIOXYGENASE; TARGET-CELLS; CUTTING EDGE; C-MAF; EXPRESSION; IL-10; INTERLEUKIN-10;

D O I：

10.1155/2016/1720827

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T regulatory cells play a key role in the control of the immune response, both in health and during illness. While the mechanisms through which T regulatory cells exert their function have been extensively described, their molecular effects on effector cells have received little attention. Thus, this revision is aimed at summarizing our current knowledge on those regulation mechanisms on the target cells from a molecular perspective.

引用

页数：12

共 80 条

[1] Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation [J].

Acehan, D ;

Jiang, XJ ;

Morgan, DG ;

Heuser, JE ;

Wang, XD ;

Akey, CW .

MOLECULAR CELL, 2002, 9 (02) :423-432

[2] Cysticerci Drive Dendritic Cells to Promote In Vitro and In Vivo Tregs Differentiation [J].

Adalid-Peralta, Laura ;

Arce-Sillas, Asiel ;

Fragoso, Gladis ;

Cardenas, Graciela ;

Rosetti, Marcos ;

Casanova-Hernandez, Didier ;

Rangel-Escareno, Claudia ;

Uribe-Figueroa, Laura ;

Fleury, Agnes ;

Sciutto, Edda .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2013,

[3] Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression [J].

Almahariq, Muayad ;

Mei, Fang C. ;

Wang, Hui ;

Cao, Anthony T. ;

Yao, Suxia ;

Soong, Lynn ;

Sun, Jiaren ;

Cong, Yingzi ;

Chen, Ju ;

Cheng, Xiaodong .

BIOCHEMICAL JOURNAL, 2015, 465 :295-303

[4] MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223) [J].

Andreae, S ;

Buisson, S ;

Triebel, F .

BLOOD, 2003, 102 (06) :2130-2137

[5] Cutting Edge: Responder T Cells Regulate Human DR+ Effector Regulatory T Cell Activity via Granzyme B [J].

Ashley, Charles W. ;

Baecher-Allan, Clare .

JOURNAL OF IMMUNOLOGY, 2009, 183 (08) :4843-4847

[6] The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation [J].

Bayer, Allison L. ;

Pugliese, Alberto ;

Malek, Thomas R. .

IMMUNOLOGIC RESEARCH, 2013, 57 (1-3) :197-209

[7] Regulatory T cells [J].

Beissert, Stefan ;

Schwarz, Agatha ;

Schwarz, Thomas .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (01) :15-24

[8] Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells [J].

Boasso, A ;

Herbeuval, JP ;

Hardy, AW ;

Winkler, C ;

Shearer, GM .

BLOOD, 2005, 105 (04) :1574-1581

[9] Expression of ectonucleotidase CD39 by Foxp3+ Treg cells:: hydrolysis of extracellular ATP and immune suppression [J].

Borsellino, Giovanna ;

Kleinewietfeld, Markus ;

Di Mitri, Diletta ;

Sternjak, Alexander ;

Diamantini, Adamo ;

Giometto, Raffaella ;

Hoepner, Sabine ;

Centonze, Diego ;

Bernardi, Giorgio ;

Dell'Acqua, Maria Luisa ;

Rossini, Paolo Maria ;

Battistini, Luca ;

Rotzschke, Olaf ;

Falk, Kirsten .

BLOOD, 2007, 110 (04) :1225-1232

[10] Apoptosis and dependence receptors: A molecular basis for cellular addiction [J].

Bredesen, DE ;

Mehlen, P ;

Rabizadeh, S .

PHYSIOLOGICAL REVIEWS, 2004, 84 (02) :411-430

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