Sunitinib for metastatic renal cell carcinoma

被引：3
作者：
Mukherji, Deborah
Larkin, James
Pickering, Lisa [1 ]
机构：
[1] Univ London St Georges Hosp, London SW17 0QT, England
来源：
FUTURE ONCOLOGY | 2010年 / 6卷 / 09期
关键词：
axitinib; bevacizumab; everolimus; pazopanib; renal cell carcinoma; sorafenib; sunitinib; temsirolimus; TYROSINE KINASE INHIBITOR; ENDOTHELIAL GROWTH-FACTOR; PLUS INTERFERON-ALPHA; PHASE-I TRIAL; ANTITUMOR-ACTIVITY; FACTOR RECEPTOR; DOUBLE-BLIND; CANCER; SURVIVAL; SU11248;
D O I：
10.2217/FON.10.94
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sunitinib is an orally available, multitargeted tyrosine kinase inhibitor licensed for 3 the treatment of metastatic renal cell carcinoma. This article is an in-depth review of the mechanism of action of sunitinib, rationale for dose and schedule, toxicity and clinical efficacy. Other targeted therapies and treatment combinations for renal cell carcinoma are discussed. The use of sunitinib for other indications, biomarkers of response and future directions are explored.
引用
收藏
页码：1377 / 1385
页数：9
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