The time to extinction for a stochastic SIS-household-epidemic model

被引:15
作者
Britton, Tom [2 ]
Neal, Peter [1 ]
机构
[1] Univ Manchester, Sch Math, Manchester M13 9PL, Lancs, England
[2] Stockholm Univ, Dept Math, S-10691 Stockholm, Sweden
基金
瑞典研究理事会;
关键词
SIS epidemics; Contact process; Households model; Time to extinction; Ornstein-Uhlenbeck process;
D O I
10.1007/s00285-009-0320-5
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We analyse a Markovian SIS epidemic amongst a finite population partitioned into households. Since the population is finite, the epidemic will eventually go extinct, i.e., have no more infectives in the population. We study the effects of population size and within household transmission upon the time to extinction. This is done through two approximations. The first approximation is suitable for all levels of within household transmission and is based upon an Ornstein-Uhlenbeck process approximation for the diseases fluctuations about an endemic level relying on a large population. The second approximation is suitable for high levels of within household transmission and approximates the number of infectious households by a simple homogeneously mixing SIS model with the households replaced by individuals. The analysis, supported by a simulation study, shows that the mean time to extinction is minimized by moderate levels of within household transmission.
引用
收藏
页码:763 / 779
页数:17
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