Wound dressing from polyvinyl alcohol/chitosan electrospun fiber membrane loaded with OH-CATH30 nanoparticles

被引：125
作者：
Zou, Pengfei [1 ]
Lee, Wen-Hui [2 ,3 ]
Gao, Zhiqin [3 ]
Qin, Di [3 ]
Wang, Yuxia [1 ]
Liu, Jiao [1 ]
Sun, Tongyi [3 ]
Gao, Yuanyuan [1 ]
机构：
[1] Weifang Med Univ, Sch Pharm, Baotong Rd, Weifang 261053, Shandong, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Key Lab Bioact Peptide Yunnan Prov, Kunming 650223, Yunnan, Peoples R China
[3] Weifang Med Univ, Sch Biosci & Technol, Key Lab Biol Med Univ Shandong Prov, Baotong Rd, Weifang 261053, Shandong, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2020年 / 232卷 / 232期
基金：
中国国家自然科学基金;
关键词：
OH-CATH30; PVA; Wound healing; Nanofibers; Nanoparticles; ANTIMICROBIAL PEPTIDE OH-CATH30; IN-VITRO; NANOFIBROUS MEMBRANE; SILVER NANOPARTICLES; EFFICIENT STRATEGY; ANTIBACTERIAL; DRUG; ALGINATE; MATS; FABRICATION;
D O I：
10.1016/j.carbpol.2019.115786
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Novel nanomaterials have been developed for antimicrobial and wound healing applications. Here, we report the preparation of a polyvinyl alcohol/chitosan (PVA/CS) nanofiber with carboxymethyl chitosan nanoparticles (CMCS-OH30 NPs) encapsulating the antibacterial peptide OH-CATH30 (OH-30). The PVA/CS nanofibers containing OH-30 NPs (NP-30-NFs) obtained via electrospinning could achieve a secondary embedded OH-30. The effect of NP-30-NFs on the release of OH-30 was investigated through high-performance liquid chromatography. The antibacterial activities of NP-30-NFs against Escherichia coli and Staphylococcus aureus were studied by bacterial plate counting. NP-30-NFs containing different concentrations of NPs were applied to mouse skin wounds to determine their effectiveness in promoting wound healing. Results showed that NP-30-NFs exhibited antibacterial properties and promoted skin wound healing.
引用
收藏
页数：10
相关论文
共 48 条
  • [31] A hybrid 3D-printed and electrospun bilayer pharmaceutical membrane based on polycaprolactone/chitosan/polyvinyl alcohol for wound healing applications
    Mehdikhani, Mehdi
    Yilgor, Pinar
    Poursamar, Seyed Ali
    Etemadi, Niloofar
    Gokyer, Seyda
    Navid, Sepehr
    Farzan, Mahan
    Farzan, Mahour
    Babaei, Melika
    Rafienia, Mohammad
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 282
  • [32] Electrospun Poly (Vinyl Alcohol) Nanofibrous Mat Loaded with Green Propolis Extract, Chitosan and Nystatin as an Innovative Wound Dressing Material
    Morais, Maria S.
    Bonfim, Daniela P. F.
    Aguiar, Monica L.
    Oliveira, Wanderley P.
    [J]. JOURNAL OF PHARMACEUTICAL INNOVATION, 2023, 18 (02) : 704 - 718
  • [33] Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application
    Wang, Siyu
    Yan, Fei
    Ren, Ping
    Li, Yi
    Wu, Qiong
    Fang, Xuedong
    Chen, Fangfang
    Wang, Ce
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 158 : 9 - 17
  • [34] Potential Wound Dressing with Antibacterial Effect from Cross-Linked Polyvinyl Alcohol/Sodium Caseinate/CuO NP Electrospun Mat
    Yilmaz, Sema Samatya
    Uzuner, Huseyin
    Aytac, Ayse
    [J]. CHEMISTRYSELECT, 2024, 9 (11):
  • [35] Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems
    Abdelgawad, Abdelrahman M.
    Hudson, Samuel M.
    Rojas, Orlando J.
    [J]. CARBOHYDRATE POLYMERS, 2014, 100 : 166 - 178
  • [36] Allicin-loaded chitosan/polyvinyl alcohol scaffolds as a potential wound dressing material to treat diabetic wounds: An in vitro and in vivo study
    Chen, Weida
    Li, Xiang
    Zeng, Li
    Pan, Hansong
    Liu, Zhichuan
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 65
  • [37] Electrospun Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide Nanofibrous Membrane with Ciprofloxacin Antibiotic Drug for Potential Wound Dressing Application
    Yang, Shuai
    Zhang, Xiaohong
    Zhang, Dawei
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (18)
  • [38] Curcumin-Loaded Co-Axial Electrospun Chitosan/Polyvinyl Alcohol/Calcium Chloride Nanofibrous Membranes for Wound Healing Enhancement
    Cao-Luu, Ngoc-Hanh
    Luong, Huynh-Vu-Thanh
    Nguyen, Tuong-Vy
    Nguyen-Thi, Bich-Thuyen
    Pham, Duy Toan
    Pham, Nhut-Cuong
    Ho, Minh-Hung
    [J]. CHEMISTRYSELECT, 2024, 9 (38):
  • [39] In vitro fibroblast migration by sustained release of PDGF-BB loaded in chitosan nanoparticles incorporated in electrospun nanofibers for wound dressing applications
    Piran, Mehrdad
    Vakilian, Saeid
    Piran, Mehran
    Mohammadi-Sangcheshmeh, Abdollah
    Hosseinzadeh, Simzar
    Ardeshirylajimi, Abdolreza
    [J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 46 : S511 - S520
  • [40] Construction and characterization of silver-loaded polyvinyl alcohol-carboxymethyl chitosan-sodium alginate hydrogel wound dressing based on 3D printing
    Chen K.
    Chai Q.
    Wang F.
    Feng C.
    Zhang D.
    [J]. Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica, 2022, 39 (12): : 5879 - 5891
12345