Wound dressing from polyvinyl alcohol/chitosan electrospun fiber membrane loaded with OH-CATH30 nanoparticles

被引：125
|
作者：
Zou, Pengfei [1 ]
Lee, Wen-Hui [2 ,3 ]
Gao, Zhiqin [3 ]
Qin, Di [3 ]
Wang, Yuxia [1 ]
Liu, Jiao [1 ]
Sun, Tongyi [3 ]
Gao, Yuanyuan [1 ]
机构：
[1] Weifang Med Univ, Sch Pharm, Baotong Rd, Weifang 261053, Shandong, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Key Lab Bioact Peptide Yunnan Prov, Kunming 650223, Yunnan, Peoples R China
[3] Weifang Med Univ, Sch Biosci & Technol, Key Lab Biol Med Univ Shandong Prov, Baotong Rd, Weifang 261053, Shandong, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2020年 / 232卷 / 232期
基金：
中国国家自然科学基金;
关键词：
OH-CATH30; PVA; Wound healing; Nanofibers; Nanoparticles; ANTIMICROBIAL PEPTIDE OH-CATH30; IN-VITRO; NANOFIBROUS MEMBRANE; SILVER NANOPARTICLES; EFFICIENT STRATEGY; ANTIBACTERIAL; DRUG; ALGINATE; MATS; FABRICATION;
D O I：
10.1016/j.carbpol.2019.115786
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Novel nanomaterials have been developed for antimicrobial and wound healing applications. Here, we report the preparation of a polyvinyl alcohol/chitosan (PVA/CS) nanofiber with carboxymethyl chitosan nanoparticles (CMCS-OH30 NPs) encapsulating the antibacterial peptide OH-CATH30 (OH-30). The PVA/CS nanofibers containing OH-30 NPs (NP-30-NFs) obtained via electrospinning could achieve a secondary embedded OH-30. The effect of NP-30-NFs on the release of OH-30 was investigated through high-performance liquid chromatography. The antibacterial activities of NP-30-NFs against Escherichia coli and Staphylococcus aureus were studied by bacterial plate counting. NP-30-NFs containing different concentrations of NPs were applied to mouse skin wounds to determine their effectiveness in promoting wound healing. Results showed that NP-30-NFs exhibited antibacterial properties and promoted skin wound healing.
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页数：10
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