Aminoglycoside (neomycin) preference is for A-form nucleic acids, not just RNA: Results from a competition dialysis study

被引：75

作者：

Arya, DP ^{[1
]}

Xue, L ^{[1
]}

Willis, B ^{[1
]}

机构：

[1] Clemson Univ, Dept Chem, Med Chem Lab, Clemson, SC 29634 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 34期

关键词：

D O I：

10.1021/ja035117c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aminoglycosides have been at the forefront of antimicrobial therapy for the past 50 years. Their specificity is believed to lie in binding duplex RNAs (rRNA). Competition dialysis studies of various nucleic acid forms with 9-aminoacridine, quinacrine, and a neomycin-acridine conjugate were carried out. Our results suggest a strong preference for aminoglycoside binding to nucleic acids that can adopt an A-type conformation. These results challenge the common belief that aminoglycoside specificity is simply for duplex RNAs. Copyright © 2003 American Chemical Society.

引用

页码：10148 / 10149

页数：2

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