Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes

被引：13

作者：

Dumoux, Maud ^{[1
]}

Nans, Andrea ^{[2
]}

Saibil, Helen R. ^{[2
]}

Hayward, Richard D. ^{[1
]}

机构：

[1] Univ Coll London & Birkbeck, Inst Struct & Mol Biol, London WC1E 7HX, England

[2] Univ London, Birkbeck Coll, Inst Struct & Mol Biol, London WC1E 7HX, England

来源：

CURRENT OPINION IN MICROBIOLOGY | 2015年 / 23卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

TRACHOMATIS INCLUSION MEMBRANE; SMALL-MOLECULE INHIBITOR; PROTEIN; ACTIN; LOCALIZATION; BACTERIA; INVASION; MEMBERS; BODIES; FAMILY;

D O I：

10.1016/j.mib.2014.09.019

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chlamydiae are obligate intracellular bacterial pathogens with an unusual biphasic lifecycle, which is underpinned by two bacterial forms of distinct structure and function. Bacterial entry and replication require a type III secretion system (T3SS), a widely conserved nanomachine responsible for the translocation of virulence effectors into host cells. Recent cell biology experiments supported by electron and cryo-electron tomography have provided fresh insights into Chlamydia host interactions. In this review, we highlight some of the recent advances, particularly the in situ analysis of T3SSs in contact with host membranes during chlamydial entry and intracellular replication, and the role of the host rough endoplasmic reticulum (rER) at the recently described intracellular 'pathogen synapse'.

引用

页码：1 / 7

页数：7

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