Synthesis of Highly Functionalized Pyridines: A Metal-Free Cascade Process

被引：8
|
作者：
Wei, Kai [1 ]
Sun, Yu-Cui [1 ]
Li, Rui [1 ]
Zhao, Jing-Feng [1 ]
Chen, Wen [1 ]
Zhang, Hongbin [1 ]
机构：
[1] Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 17期
基金：
中国国家自然科学基金;
关键词：
SUBSTITUTED PYRIDINES; CONDENSATION; COMPLEXES; ACCESS;
D O I：
10.1021/acs.orglett.1c02234
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report a new process for the synthesis of highly functionalized pyridines based on a tandem Pummerer-type rearrangement, aza-Prins cyclization, and elimination-induced aromatization. This formal [5+1] cyclization provides pyridines in good yields with easily accessible starting materials. The synthetic potential of our new method is further demonstrated in the modification of the frameworks of BINOL and some natural products.
引用
收藏
页码：6669 / 6673
页数：5
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