Nanoparticulate Alternatives for Drug Delivery

被引：174

作者：

Adair, James H. ^{[1
,2
]}

Parette, Mylisa P. ^{[2
]}

Altinoglu, Erhan I. ^{[1
]}

Kester, Mark ^{[2
,3
]}

机构：

[1] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA

[2] Keytone Nano Inc, State Coll, PA 16803 USA

[3] Penn State Milton S Hershey Med Ctr, Dept Pharmacol, Hershey, PA 17033 USA

来源：

ACS NANO | 2010年 / 4卷 / 09期

关键词：

PHOSPHATE NANOCOMPOSITE PARTICLES; CALCIUM-PHOSPHATE; CANCER;

D O I：

10.1021/nn102324e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ability to apply nanomaterials as targeted delivery agents for drugs and other therapeutics holds promise for a wide variety of diseases, including many types of cancer. A nanodelivery vehicle must demonstrate in vivo efficacy, diminished or no toxicity, stability, improved pharmacokinetics, and controlled-release kinetics. In this issue, Lee et al. construct polymer nanobins that fulfill these requirements and demonstrate effective delivery of doxorubicin in vivo to breast cancer cells. This Perspective explores the outlook for these nanobins as well as other technologies in this field and the challenges that lie ahead.

引用

页码：4967 / 4970

页数：4

共 14 条

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