Paroxetine shifts imipramine metabolism

被引：47

作者：

Albers, LJ ^{[1
]}

Reist, C ^{[1
]}

Helmeste, D ^{[1
]}

Vu, R ^{[1
]}

Tang, SW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT PSYCHIAT & HUMAN BEHAV,MED CTR,ORANGE,CA 92668

来源：

PSYCHIATRY RESEARCH | 1996年 / 59卷 / 03期

关键词：

antidepressant; tricyclic; serotonin reuptake inhibitor; desipramine; human cytochrome P450; pharmacokinetics;

D O I：

10.1016/0165-1781(95)02822-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The combination of selective serotonin reuptake inhibitors with tricyclic antidepressants has proven useful in treatment-resistant depression but has the potential for adverse drug-drug interactions. In the present study, the metabolism of a single dose of imipramine was studied before and after treatment with paroxetine. Paroxetine induced significant elevations of approximately 50% in half-life, area under the curve, and C-max of imipramine and decreased clearance twofold. The effects on desipramine pharmacokinetics were even more pronounced. These findings indicate a significant interaction of paroxetine with the CYP2D6 isoenzyme.

引用

页码：189 / 196

页数：8

共 25 条

[1]

ALDERMAN JA, 1994, ANN M AM PSYCH ASS P

[2] HYDROXYLATION POLYMORPHISMS OF DEBRISOQUINE AND MEPHENYTOIN IN EUROPEAN POPULATIONS [J].

ALVAN, G ;

BECHTEL, P ;

ISELIUS, L ;

GUNDERTREMY, U .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1990, 39 (06) :533-537

[3]

ARANOW RB, 1989, AM J PSYCHIAT, V146, P911

[4] RAPID DOWN REGULATION OF BETA-ADRENOCEPTORS BY CO-ADMINISTRATION OF DESIPRAMINE AND FLUOXETINE [J].

BARON, BM ;

OGDEN, AM ;

SIEGEL, BW ;

STEGEMAN, J ;

URSILLO, RC ;

DUDLEY, MW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 154 (02) :125-134

[5]

BARROS J, 1993, AM J PSYCHIAT, V150, P1751

[6] QUANTIFICATION AND MECHANISM OF THE FLUOXETINE AND TRICYCLIC ANTIDEPRESSANT INTERACTION [J].

BERGSTROM, RF ;

PEYTON, AL ;

LEMBERGER, L .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1992, 51 (03) :239-248

[7] DETERMINATION OF PAROXETINE IN HUMAN-PLASMA, USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION [J].

BRETT, MA ;

DIERDORF, HD ;

ZUSSMAN, BD ;

COATES, PE .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 419 :438-444

[8] INHIBITION BY PAROXETINE OF DESIPRAMINE METABOLISM IN EXTENSIVE BUT NOT IN POOR METABOLIZERS OF SPARTEINE [J].

BROSEN, K ;

HANSEN, JG ;

NIELSEN, KK ;

SINDRUP, SH ;

GRAM, LF .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1993, 44 (04) :349-355

[9] ROLE OF P450IID6, THE TARGET OF THE SPARTEINE-DEBRISOQUIN OXIDATION POLYMORPHISM, IN THE METABOLISM OF IMIPRAMINE [J].

BROSEN, K ;

ZEUGIN, T ;

MEYER, UA .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1991, 49 (06) :609-617

[10] THE EFFECT OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS ON CYTOCHROME-P4502D6 (CYP2D6) ACTIVITY IN HUMAN LIVER-MICROSOMES [J].

CREWE, HK ;

LENNARD, MS ;

TUCKER, GT ;

WOODS, FR ;

HADDOCK, RE .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 34 (03) :262-265

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