Hepatitis C virus and interferon resistance

被引：38
作者：
Taylor, DR
Shi, ST
Lai, MMC
机构：
[1] Univ So Calif, Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90089 USA
[2] Howard Hughes Med Inst, Los Angeles, CA 90089 USA
来源：
MICROBES AND INFECTION | 2000年 / 2卷 / 14期
基金：
美国国家卫生研究院;
关键词：
interferon; hepatitis C virus; protein kinase; PKR;
D O I：
10.1016/S1286-4579(00)01329-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interferon plays a critical role in the host's natural defense against viral infections and in their treatment. It is the only therapy for hepatitis C virus (HCV) infection; however, many virus isolates are resistant. Several HCV proteins have been shown to possess properties that enable the virus to evade the interferon-mediated cellular antiviral responses. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：1743 / 1756
页数：14
相关论文
共 165 条
[41]   Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein [J].
Fukuma, T ;
Enomoto, N ;
Marumo, F ;
Sato, C .
HEPATOLOGY, 1998, 28 (04) :1147-1153
[42]   Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: Molecular mechanisms of kinase regulation [J].
Gale, M ;
Blakely, CM ;
Kwieciszewski, B ;
Tan, SL ;
Dossett, M ;
Tang, NM ;
Korth, MJ ;
Polyak, SJ ;
Gretch, DR ;
Katze, MG .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (09) :5208-5218
[43]   Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein [J].
Gale, MJ ;
Korth, MJ ;
Tang, NM ;
Tan, SL ;
Hopkins, DA ;
Dever, TE ;
Polyak, SJ ;
Gretch, DR ;
Katze, MG .
VIROLOGY, 1997, 230 (02) :217-227
[44]   Evidence for sequence selection within the non-structural 5A gene of hepatitis C virus type 1b during unsuccessful treatment with interferon-α [J].
Gerotto, M ;
Dal Pero, F ;
Sullivan, DG ;
Chemello, L ;
Cavalletto, L ;
Polyak, SJ ;
Pontisso, P ;
Gretch, DR ;
Alberti, A .
JOURNAL OF VIRAL HEPATITIS, 1999, 6 (05) :367-372
[45]   Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth [J].
Ghosh, AK ;
Steele, R ;
Meyer, K ;
Ray, R ;
Ray, RB .
JOURNAL OF GENERAL VIROLOGY, 1999, 80 :1179-1183
[46]  
GILMOUR KC, 1995, GENE EXPRESSION, V5, P1
[47]   Modulation of hepatitis C virus quasispecies heterogeneity by interferon-alpha and ribavirin therapy [J].
GonzalezPeralta, RP ;
Liu, WZ ;
Davis, GL ;
Qian, KP ;
Lau, JYN .
JOURNAL OF VIRAL HEPATITIS, 1997, 4 (02) :99-106
[48]   LIGAND-INDUCED IFN-GAMMA RECEPTOR TYROSINE PHOSPHORYLATION COUPLES THE RECEPTOR TO ITS SIGNAL-TRANSDUCTION SYSTEM (P91) [J].
GREENLUND, AC ;
FARRAR, MA ;
VIVIANO, BL ;
SCHREIBER, RD .
EMBO JOURNAL, 1994, 13 (07) :1591-1600
[49]   Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients [J].
Gretch, DR ;
Polyak, SJ ;
Wilson, JJ ;
Carithers, RL ;
Perkins, JD ;
Corey, L .
JOURNAL OF VIROLOGY, 1996, 70 (11) :7622-7631
[50]   CYTOKINE THERAPEUTICS - LESSONS FROM INTERFERON-ALPHA [J].
GUTTERMAN, JU .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (04) :1198-1205
12345678910