Hepatitis C virus and interferon resistance

被引：38
作者：
Taylor, DR
Shi, ST
Lai, MMC
机构：
[1] Univ So Calif, Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90089 USA
[2] Howard Hughes Med Inst, Los Angeles, CA 90089 USA
来源：
MICROBES AND INFECTION | 2000年 / 2卷 / 14期
基金：
美国国家卫生研究院;
关键词：
interferon; hepatitis C virus; protein kinase; PKR;
D O I：
10.1016/S1286-4579(00)01329-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interferon plays a critical role in the host's natural defense against viral infections and in their treatment. It is the only therapy for hepatitis C virus (HCV) infection; however, many virus isolates are resistant. Several HCV proteins have been shown to possess properties that enable the virus to evade the interferon-mediated cellular antiviral responses. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：1743 / 1756
页数：14
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