Cadmium, arsenic, selenium and iron- Implications for tumor progression in breast cancer

被引：57
|
作者：
Jablonska, E. [1 ]
Socha, K. [2 ]
Reszka, E. [1 ]
Wieczorek, E. [1 ]
Skokowski, J. [3 ,4 ,5 ]
Kalinowski, L. [3 ,4 ,5 ]
Fendler, W. [6 ]
Seroczynska, B. [3 ,4 ,5 ]
Wozniak, M. [3 ,4 ,5 ]
Borawska, M. H. [2 ]
Wasowicz, W. [7 ]
机构：
[1] Nofer Inst Occupat Med, Dept Mol Genet & Epigenet, Teresy 8 Str, PL-91348 Lodz, Poland
[2] Med Univ Bialystok, Dept Bromatol, A Mickiewicza 2D Str, PL-15222 Bialystok, Poland
[3] Med Univ Gdansk, Dept Surg Oncol, M Smoluchowskiego 17 Str, PL-80952 Gdansk, Poland
[4] Dept Med Lab Diagnost, Debinki 7, PL-80211 Gdansk, Poland
[5] Bank Frozen Tissues & Genet Specimens, Debinki 7, PL-80211 Gdansk, Poland
[6] Med Univ Lodz, Dept Pediat Oncol Hematol & Diabetol, Sporna 35-50 Str, PL-91738 Lodz, Poland
[7] Nofer Inst Occupat Med, Dept Biol & Environm Monitoring, Teresy 8 Str, PL-91348 Lodz, Poland
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2017年 / 53卷
关键词：
Cadmium; Arsenic; Selenium; Iron; Breast cancer; ESTROGEN-RECEPTOR; UPDATED METAANALYSIS; URINARY CADMIUM; RISK; GROWTH; ASSOCIATION; EXPOSURE; CELLS; INHIBITION; EXPRESSION;
D O I：
10.1016/j.etap.2017.05.014
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The aim of this study was to determine Cd (cadmium) and As (arsenic) contents in human breast cancer tissues, investigate their interactions with Se (selenium) and Fe (iron), and assess their further implications for tumor progression. Metal contents were determined in 42 tissue sets (tumor and adjacent tissue) collected from 42 women diagnosed with primary breast cancer. Analytical methods included AAS and ICP-MS techniques. Significantly higher contents of Cd (p = 0.0003), Se (p < 0.0001) and Fe (p = 0.0441) whereas significantly lower content of As (p < 0.0001) were observed in tumors as compared to adjacent tissues. There was a significant positive correlation between Cd and As contents in tumor tissue. However, only Cd was significantly associated with histological type of tumor, its size, grading and progesterone receptor status. This study support the role of Cd in breast cancer risk and progression. The possible link between As exposure and breast cancer is still not clear.
引用
收藏
页码：151 / 157
页数：7
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