Cracking the death code: apoptosis-related histone modifications

被引：91

作者：

Fullgrabe, J. ^{[1
]}

Hajji, N. ^{[1
]}

Joseph, B. ^{[1
]}

机构：

[1] Karolinska Inst, Canc Ctr Karolinska, Dept Oncol Pathol, S-17176 Stockholm, Sweden

来源：

CELL DEATH AND DIFFERENTIATION | 2010年 / 17卷 / 08期

基金：

瑞典研究理事会;

关键词：

apoptosis; histone modification; epigenetic; DOUBLE-STRAND BREAKS; DNA-DAMAGE RESPONSE; CHROMATIN CONDENSATION; NUCLEOSOME MOBILITY; THYMOCYTE APOPTOSIS; H4-K16; ACETYLATION; STERILE-20; KINASE; EPIGENETIC CODE; S; CEREVISIAE; EYES ABSENT;

D O I：

10.1038/cdd.2010.58

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The degradation and compaction of chromatin are long-standing hallmark features of apoptosis. The histones, chief protein components of chromatin, are subjected to a wide range of post-translational modifications. An increasing body of evidence suggests that combinations of epigenetic histone modifications influence the overall chromatin structure and have clear functional consequences in cellular processes including apoptosis. This review describes the work to date on the post-translational modification of histones during apoptosis, their regulation by enzymatic complexes and discusses the existence of the apoptotic histone code. Cell Death and Differentiation (2010) 17, 1238-1243; doi:10.1038/cdd.2010.58; published online 14 May 2010

引用

页码：1238 / 1243

页数：6

共 54 条

[1] Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae [J].