Formation and stabilization of ibuprofen nanoparticles by pulsed rapid expansion of supercritical solutions

被引：22

作者：

Hermsdorf, Dana ^{[1
]}

Jauer, Stephan ^{[1
]}

Signorell, Ruth ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

MOLECULAR PHYSICS | 2007年 / 105卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1080/00268970701222714

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Pulsed rapid expansion of supercritical solutions (RESS) was used to micronize racemic ibuprofen and S-ibuprofen. The characterization of the particles was carried out with rapid-scan infrared spectroscopy in situ, 3-wavelengths-extinction measurements, a scanning mobility particle sizer, scanning electron microscopy, and X-ray diffraction. We observed the formation of nanosized primary particles that coagulate and agglomerate strongly to form large chains of many microns in size. It is investigated where the coagulation/agglomeration processes take place and we demonstrate that it is possible to avoid these processes by forming mixed ibuprofen/polymer particles. The stabilization of separate particles depends strongly on the amount of polymer in the particles. Our specially designed RESS apparatus with two different extractor units allows us to vary the fraction of polymer systematically.

引用

页码：951 / 959

页数：9

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