Cutaneous metastasis of cecum cancer with MSI-high and BRAFV600E mutation: a case report

被引:1
作者
Yunoki, Kosuke [1 ]
Yano, Takuya [1 ]
Yoshimitsu, Masanori [1 ]
Oshita, Ko [1 ]
Kubota, Tetsushi [1 ]
Ishida, Michihiro [1 ]
Satoh, Daisuke [1 ]
Choda, Yasuhiro [1 ]
Nakano, Kanyu [1 ]
Shirakawa, Yasuhiro [1 ]
Matsukawa, Hiroyoshi [1 ]
Idani, Hitoshi [1 ]
Shiozaki, Shigehiro [1 ]
Okajima, Masazumi [1 ,2 ]
机构
[1] Hiroshima City Hiroshima Citizens Hosp, Dept Surg, Naka Ku, 7-33 Motomachi, Hiroshima 7308518, Japan
[2] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Gastroenterol & Transplant Surg, Appl Life Sci,Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan
关键词
Colon cancer; Cutaneous metastasis; Microsatellite instability; BRAFV600E; Case report; MISMATCH REPAIR; MICROSATELLITE-INSTABILITY; COLORECTAL-CANCER; BRAF MUTATION; COLON-CANCER; CARCINOMA; BENEFIT; CELLS;
D O I
10.1186/s40792-021-01265-w
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background Cutaneous metastases of colorectal cancer (CRC) are rare, occurring in 0.7% to 5% of cancer patients. Furthermore, the molecular subtypes of cutaneous metastasis of CRC are unclear. Here, we present a rare case of cutaneous metastasis of high-frequency microsatellite instability (MSI-high)/BRAFV600E-mutant cecum cancer. Case presentation A 77-year-old woman presented at the outpatient clinic with a subcutaneous mass on her left back. An excisional biopsy was performed and metastatic cutaneous adenocarcinoma was diagnosed. A computed tomography scan of the thorax and abdomen showed thickening of the cecum wall, the presence of pericolic lymph nodes, multiple masses in the liver, and a single nodule in the right lung. Right colectomy with D2 lymphadenectomy and functional end-to-end anastomosis was performed because of the almost-complete intestinal obstruction. The expression of KRAS wild type, BRAFV600E mutation, and MSI-high was detected in the cecum cancer using molecular pathological examination. She received chemotherapy with XELOX + BEV regimen (capecitabine + oxaliplatin + bevacizumab). After four administrations, a computed tomography scan showed reduction of distant metastases, which suggested partial response. Conclusions We encountered a rare case of cutaneous metastasis of MSI-high and BRAFV600E-mutant cecum cancer. In the future, it will be necessary to accumulate more cases to identify clinical features and more effective treatments for CRCs with cutaneous metastasis.
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