Regulation of Genome Architecture and Function by Polycomb Proteins

被引：79
|
作者：
Entrevan, Marianne [1 ,2 ]
Schuettengruber, Bernd [1 ,2 ]
Cavalli, Giacomo [1 ,2 ]
机构：
[1] CNRS, Inst Human Genet, UPR1142, 141 Rue Cardonille, F-34396 Montpellier 5, France
[2] Univ Montpellier, 141 Rue Cardonille, F-34396 Montpellier 5, France
来源：
TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 07期
基金：
欧洲研究理事会; 欧盟地平线“2020”;
关键词：
EMBRYONIC STEM-CELLS; RNA-POLYMERASE-II; HISTONE METHYLTRANSFERASE ACTIVITY; REPRESSIVE COMPLEX 1; H3; LYSINE; 27; H2A UBIQUITYLATION; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; NUCLEOSOME-BINDING; CHROMATIN DOMAINS;
D O I：
10.1016/j.tcb.2016.04.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Polycomb group (PcG) proteins dynamically define cellular identities through the epigenetic repression of key developmental regulatory genes. PcG proteins are recruited to specific regulatory elements to modify the chromatin surrounding them. In addition, they regulate the organization of their target genes in the 3D space of the nucleus, and this regulatory function of the 3D genome architecture is involved in cell differentiation and the maintenance of cellular memory. In this review we discuss recent advances in our understanding of how PcG proteins are recruited to chromatin to induce local and global changes in chromosome conformation and regulate their target genes.
引用
收藏
页码：511 / 525
页数：15
相关论文
共 50 条
  • [31] Know when to fold 'em: Polycomb complexes in oncogenic 3D genome regulation
    Doyle, Emma J. J.
    Morey, Lluis
    Conway, Eric
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
  • [32] Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer
    Laugesen, Anne
    Hojfeldt, Jonas Westergaard
    Helin, Kristian
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2016, 6 (09):
  • [33] Roles of Polycomb Complexes in the Reconstruction of 3D Genome Architecture during Preimplantation Embryonic Development
    Yu, Longtao
    Shen, Hengxiang
    Lyu, Xiaowen
    GENES, 2022, 13 (12)
  • [34] Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners
    Struebbe, Gero
    Popp, Christian
    Schmidt, Alexander
    Pauli, Andrea
    Ringrose, Leonie
    Beisel, Christian
    Paro, Renato
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (14) : 5572 - 5577
  • [35] Polycomb group proteins in hematopoietic stem cell aging and malignancies
    Klauke, Karin
    de Haan, Gerald
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2011, 94 (01) : 11 - 23
  • [36] Control of the Gene Activity by Polycomb and Trithorax Group Proteins in Drosophila
    Chetverina, D. A.
    Elizar'ev, P. V.
    Lomaev, D. V.
    Georgiev, P. G.
    Erokhin, M. M.
    RUSSIAN JOURNAL OF GENETICS, 2017, 53 (02) : 157 - 177
  • [37] Interaction between Polycomb and SSX Proteins in Pericentromeric Heterochromatin Function and Its Implication in Cancer
    Johansen, Simone
    Gjerstorff, Morten Frier
    CELLS, 2020, 9 (01)
  • [38] Polycomb Group Proteins Set the Stage for Early Lineage Commitment
    Surface, Lauren E.
    Thornton, Seraphim R.
    Boyer, Laurie A.
    CELL STEM CELL, 2010, 7 (03) : 288 - 298
  • [39] Functions of Polycomb Proteins on Active Targets
    Giner-Laguarda, Natalia
    Vidal, Miguel
    EPIGENOMES, 2020, 4 (03)
  • [40] Polycomb group proteins and their roles in carcinogenesis
    Xiao LanBo
    Tao YongGuang
    Li LiLi
    Cao Ya
    CHINESE SCIENCE BULLETIN, 2012, 57 (18): : 2259 - 2264
12345