Regulation of Genome Architecture and Function by Polycomb Proteins

被引：79
|
作者：
Entrevan, Marianne [1 ,2 ]
Schuettengruber, Bernd [1 ,2 ]
Cavalli, Giacomo [1 ,2 ]
机构：
[1] CNRS, Inst Human Genet, UPR1142, 141 Rue Cardonille, F-34396 Montpellier 5, France
[2] Univ Montpellier, 141 Rue Cardonille, F-34396 Montpellier 5, France
来源：
TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 07期
基金：
欧洲研究理事会; 欧盟地平线“2020”;
关键词：
EMBRYONIC STEM-CELLS; RNA-POLYMERASE-II; HISTONE METHYLTRANSFERASE ACTIVITY; REPRESSIVE COMPLEX 1; H3; LYSINE; 27; H2A UBIQUITYLATION; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; NUCLEOSOME-BINDING; CHROMATIN DOMAINS;
D O I：
10.1016/j.tcb.2016.04.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Polycomb group (PcG) proteins dynamically define cellular identities through the epigenetic repression of key developmental regulatory genes. PcG proteins are recruited to specific regulatory elements to modify the chromatin surrounding them. In addition, they regulate the organization of their target genes in the 3D space of the nucleus, and this regulatory function of the 3D genome architecture is involved in cell differentiation and the maintenance of cellular memory. In this review we discuss recent advances in our understanding of how PcG proteins are recruited to chromatin to induce local and global changes in chromosome conformation and regulate their target genes.
引用
收藏
页码：511 / 525
页数：15
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