Regulation of Genome Architecture and Function by Polycomb Proteins

被引：81
作者：
Entrevan, Marianne [1 ,2 ]
Schuettengruber, Bernd [1 ,2 ]
Cavalli, Giacomo [1 ,2 ]
机构：
[1] CNRS, Inst Human Genet, UPR1142, 141 Rue Cardonille, F-34396 Montpellier 5, France
[2] Univ Montpellier, 141 Rue Cardonille, F-34396 Montpellier 5, France
来源：
TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 07期
基金：
欧洲研究理事会; 欧盟地平线“2020”;
关键词：
EMBRYONIC STEM-CELLS; RNA-POLYMERASE-II; HISTONE METHYLTRANSFERASE ACTIVITY; REPRESSIVE COMPLEX 1; H3; LYSINE; 27; H2A UBIQUITYLATION; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; NUCLEOSOME-BINDING; CHROMATIN DOMAINS;
D O I：
10.1016/j.tcb.2016.04.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Polycomb group (PcG) proteins dynamically define cellular identities through the epigenetic repression of key developmental regulatory genes. PcG proteins are recruited to specific regulatory elements to modify the chromatin surrounding them. In addition, they regulate the organization of their target genes in the 3D space of the nucleus, and this regulatory function of the 3D genome architecture is involved in cell differentiation and the maintenance of cellular memory. In this review we discuss recent advances in our understanding of how PcG proteins are recruited to chromatin to induce local and global changes in chromosome conformation and regulate their target genes.
引用
收藏
页码：511 / 525
页数：15
相关论文
共 132 条
[1]   The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development [J].
Anderson, Aimee E. ;
Karandikar, Umesh C. ;
Pepple, Kathryn L. ;
Chen, Zhihong ;
Bergmann, Andreas ;
Mardon, Graeme .
DEVELOPMENT, 2011, 138 (10) :1957-1966
[2]   Regulation of gene transcription by Polycomb proteins [J].
Aranda, Sergi ;
Mas, Gloria ;
Di Croce, Luciano .
SCIENCE ADVANCES, 2015, 1 (11)
[3]   RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins [J].
Arora, Mansi ;
Packard, Colin Z. ;
Banerjee, Tapahsama ;
Parvin, Jeffrey D. .
NUCLEIC ACIDS RESEARCH, 2016, 44 (05) :2136-2144
[4]   A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner [J].
Attwooll, C ;
Oddi, S ;
Cartwright, P ;
Prosperini, E ;
Agger, K ;
Steensgaard, P ;
Wagener, C ;
Sardet, C ;
Moroni, MC ;
Helin, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (02) :1199-1208
[5]   Inheritance of Polycomb-dependent chromosomal interactions in Drosophila [J].
Bantignies, F ;
Grimaud, C ;
Lavrov, S ;
Gabut, M ;
Cavalli, G .
GENES & DEVELOPMENT, 2003, 17 (19) :2406-2420
[6]   Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila [J].
Bantignies, Frederic ;
Roure, Virginie ;
Comet, Itys ;
Leblanc, Benjamin ;
Schuettengruber, Bernd ;
Bonnet, Jerome ;
Tixier, Vanessa ;
Mas, Andre ;
Cavalli, Giacomo .
CELL, 2011, 144 (02) :214-226
[7]   YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment [J].
Basu, Arindam ;
Wilkinson, Frank H. ;
Colavita, Kristen ;
Fennelly, Colin ;
Atchison, Michael L. .
NUCLEIC ACIDS RESEARCH, 2014, 42 (04) :2208-2223
[8]  
Bauer M., 2015, CHROMOSOMA
[9]   Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation [J].
Blackledge, Neil P. ;
Farcas, Anca M. ;
Kondo, Takashi ;
King, Hamish W. ;
McGouran, Joanna F. ;
Hanssen, Lars L. P. ;
Ito, Shinsuke ;
Cooper, Sarah ;
Kondo, Kaori ;
Koseki, Yoko ;
Ishikura, Tomoyuki ;
Long, Hannah K. ;
Sheahan, Thomas W. p ;
Brockdorff, Neil ;
Kessler, Benedikt M. ;
Koseki, Haruhiko ;
Klose, Robert J. .
CELL, 2014, 157 (06) :1445-1459
[10]   Super-resolution imaging reveals distinct chromatin folding for different epigenetic states [J].
Boettiger, Alistair N. ;
Bintu, Bogdan ;
Moffitt, Jeffrey R. ;
Wang, Siyuan ;
Beliveau, Brian J. ;
Fudenberg, Geoffrey ;
Imakaev, Maxim ;
Mirny, Leonid A. ;
Wu, Chao-ting ;
Zhuang, Xiaowei .
NATURE, 2016, 529 (7586) :418-+
12345678910