Toll-like Receptor 2 as a Marker Molecule of Advanced Ovarian Cancer

被引：7

作者：

Sobstyl, Malgorzata ^{[1
]}

Niedzwiedzka-Rystwej, Paulina ^{[2
]}

Hrynkiewicz, Rafal ^{[2
]}

Bebnowska, Dominika ^{[2
]}

Korona-Glowniak, Izabela ^{[3
]}

Pasiarski, Marcin ^{[4
,5
]}

Sosnowska-Pasiarska, Barbara ^{[6
]}

Smok-Kalwat, Jolanta ^{[7
]}

Gozdz, Stanislaw ^{[7
,8
]}

Sobstyl, Anna ^{[9
]}

Polkowski, Wojciech ^{[10
]}

Rolinski, Jacek ^{[9
]}

Grywalska, Ewelina ^{[9
]}

机构：

[1] Med Univ Lublin, Dept Gynecol & Gynecol Endocrinol, PL-20037 Lublin, Poland

[2] Univ Szczecin, Inst Biol, PL-71412 Szczecin, Poland

[3] Med Univ Lublin, Dept Pharmaceut Microbiol, PL-20093 Lublin, Poland

[4] Jan Kochanowski Univ, Fac Hlth Sci, Dept Immunol, PL-25317 Kielce, Poland

[5] Holy Cross Canc Ctr, Dept Hematol, PL-25734 Kielce, Poland

[6] Holy Cross Canc Ctr, Dept Oncocardiol, PL-25734 Kielce, Poland

[7] Holy Cross Canc Ctr, Dept Clin Oncol, PL-25734 Kielce, Poland

[8] Jan Kochanowski Univ, Fac Med & Hlth Sci, PL-25516 Kielce, Poland

[9] Med Univ Lublin, Dept Clin Immunol & Immunotherapy, PL-20093 Lublin, Poland

[10] Med Univ Lublin, Dept Surg Oncol, Radziwillowska 13 St, PL-20080 Lublin, Poland

来源：

BIOMOLECULES | 2021年 / 11卷 / 08期

关键词：

Toll-like receptor; TLR2; ovarian cancer; biomarker; receptor; expression; EPIDEMIOLOGY; EXPRESSION; DIAGNOSIS; WOMEN; RISK;

D O I：

10.3390/biom11081205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ovarian cancer is a global problem that affects women of all ages. Due to the lack of effective screening tests and the usually asymptomatic course of the disease in the early stages, the diagnosis is too late, with the result that less than half of the patients diagnosed with ovarian cancer (OC) survive more than five years after their diagnosis. In this study, we examined the expression of TLR2 in the peripheral blood of 50 previously untreated patients with newly diagnosed OC at various stages of the disease using flow cytometry. The studies aimed at demonstrating the usefulness of TLR2 as a biomarker in the advanced stage of ovarian cancer. In this study, we showed that TLR2 expression levels were significantly higher in women with more advanced OC than in women in the control group. Our research sheds light on the prognostic potential of TLR2 in developing new diagnostic approaches and thus in increasing survival in patients with confirmed ovarian cancer.

引用

页数：12

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[41] Toll-like receptor 2 (TLR2) is a marker of angiogenesis in the necrotic area of human medulloblastoma [J].

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