Toll-like Receptor 2 as a Marker Molecule of Advanced Ovarian Cancer

被引：6

作者：

Sobstyl, Malgorzata ^{[1
]}

Niedzwiedzka-Rystwej, Paulina ^{[2
]}

Hrynkiewicz, Rafal ^{[2
]}

Bebnowska, Dominika ^{[2
]}

Korona-Glowniak, Izabela ^{[3
]}

Pasiarski, Marcin ^{[4
,5
]}

Sosnowska-Pasiarska, Barbara ^{[6
]}

Smok-Kalwat, Jolanta ^{[7
]}

Gozdz, Stanislaw ^{[7
,8
]}

Sobstyl, Anna ^{[9
]}

Polkowski, Wojciech ^{[10
]}

Rolinski, Jacek ^{[9
]}

Grywalska, Ewelina ^{[9
]}

机构：

[1] Med Univ Lublin, Dept Gynecol & Gynecol Endocrinol, PL-20037 Lublin, Poland

[2] Univ Szczecin, Inst Biol, PL-71412 Szczecin, Poland

[3] Med Univ Lublin, Dept Pharmaceut Microbiol, PL-20093 Lublin, Poland

[4] Jan Kochanowski Univ, Fac Hlth Sci, Dept Immunol, PL-25317 Kielce, Poland

[5] Holy Cross Canc Ctr, Dept Hematol, PL-25734 Kielce, Poland

[6] Holy Cross Canc Ctr, Dept Oncocardiol, PL-25734 Kielce, Poland

[7] Holy Cross Canc Ctr, Dept Clin Oncol, PL-25734 Kielce, Poland

[8] Jan Kochanowski Univ, Fac Med & Hlth Sci, PL-25516 Kielce, Poland

[9] Med Univ Lublin, Dept Clin Immunol & Immunotherapy, PL-20093 Lublin, Poland

[10] Med Univ Lublin, Dept Surg Oncol, Radziwillowska 13 St, PL-20080 Lublin, Poland

来源：

BIOMOLECULES | 2021年 / 11卷 / 08期

关键词：

Toll-like receptor; TLR2; ovarian cancer; biomarker; receptor; expression; EPIDEMIOLOGY; EXPRESSION; DIAGNOSIS; WOMEN; RISK;

D O I：

10.3390/biom11081205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ovarian cancer is a global problem that affects women of all ages. Due to the lack of effective screening tests and the usually asymptomatic course of the disease in the early stages, the diagnosis is too late, with the result that less than half of the patients diagnosed with ovarian cancer (OC) survive more than five years after their diagnosis. In this study, we examined the expression of TLR2 in the peripheral blood of 50 previously untreated patients with newly diagnosed OC at various stages of the disease using flow cytometry. The studies aimed at demonstrating the usefulness of TLR2 as a biomarker in the advanced stage of ovarian cancer. In this study, we showed that TLR2 expression levels were significantly higher in women with more advanced OC than in women in the control group. Our research sheds light on the prognostic potential of TLR2 in developing new diagnostic approaches and thus in increasing survival in patients with confirmed ovarian cancer.

引用

页数：12

共 50 条

[21] Toll-Like Receptor 2 or Toll-Like Receptor 4 Deficiency Does Not Modify Lupus in MRLlpr Mice
Freeley, Simon J.
Giorgini, Angela
Tulone, Calogero
Popat, Reena J.
Horsfield, Catherine
Robson, Michael G.
PLOS ONE, 2013, 8 (09):
[22] Function and Phenotype of Microglia Are Determined by Toll-Like Receptor 2/Toll-Like Receptor 4 Activation Sequence
Li, Weixin
Gao, Guodong
Guo, Qingdong
Jia, Dong
Wang, Julei
Wang, Xuelian
He, Shiming
Liang, Qinchuan
DNA AND CELL BIOLOGY, 2009, 28 (10) : 493 - 499
[23] Toll-like receptor 2 and toll-like receptor 4 expression in human adrenals
Bornstein, SR
Schumann, RR
Rettori, V
McCann, SM
Zacharowski, K
HORMONE AND METABOLIC RESEARCH, 2004, 36 (07) : 470 - 473
[24] Ulvan Activates Chicken Heterophils and Monocytes Through Toll-Like Receptor 2 and Toll-Like Receptor 4
Guriec, Nathalie
Bussy, Frederick
Gouin, Christelle
Mathiaud, Olivier
Quero, Benoit
Le Goff, Matthieu
Collen, Pi Nyvall
FRONTIERS IN IMMUNOLOGY, 2018, 9
[25] Expression of toll-like receptors in ovarian cancer
Vlad, Catalin
Dina, Constantin
Kubelac, Paul
Vlad, Diana
Pop, Bogdan
Achimas-Cadariu, Patriciu
JOURNAL OF BUON, 2018, 23 (06): : 1725 - 1731
[26] Toll-like receptor 4 genetic variants and prognosis of breast cancer
Yang, C-X
Li, C-Y
Feng, W.
TISSUE ANTIGENS, 2013, 81 (04): : 221 - 226
[27] Toll-like Receptor 4 Gene Polymorphisms and Susceptibility to Bladder Cancer
Shen, Yizhen
Liu, Yi
Liu, Shaoge
Zhang, Aimin
PATHOLOGY & ONCOLOGY RESEARCH, 2013, 19 (02) : 275 - 280
[28] Polymorphisms in Toll-like Receptor Genes - Implications for Prostate Cancer Development
Vidas, Zeljko
COLLEGIUM ANTROPOLOGICUM, 2010, 34 (02) : 779 - 783
[29] Involvement of toll-like receptor 9 polymorphism in cervical cancer development
Roszak, Andrzej
Lianeri, Margarita
Sowinska, Anna
Jagodzinski, Pawel P.
MOLECULAR BIOLOGY REPORTS, 2012, 39 (08) : 8425 - 8430
[30] The role of Toll-like receptor 4 signaling pathway in ovarian, cervical, and endometrial cancers
Lupi, Luiz Antonio
Cucielo, Maira Smaniotto
Silveira, Henrique Spaulonci
Gaiotte, Leticia Barbosa
Cesario, Roberta Carvalho
Ferreira Seiva, Fabio Rodrigues
de Almeida Chuffa, Luiz Gustavo
LIFE SCIENCES, 2020, 247

← 1 2 3 4 5 →