How to detect carbapenemase producers? A literature review of phenotypic and molecular methods

被引：52

作者：

Hammoudi, D. ^{[1
,2
]}

Moubareck, C. Ayoub ^{[1
,2
,3
]}

Sarkis, D. Karam ^{[1
,2
]}

机构：

[1] St Joseph Univ, Sch Pharm, Microbiol Lab, Beirut, Lebanon

[2] Rodolph Merieux Lab, Beirut, Lebanon

[3] Zayed Univ, Coll Sustainabil Sci & Humanities, Dept Nat Sci & Publ Hlth, Dubai, U Arab Emirates

来源：

JOURNAL OF MICROBIOLOGICAL METHODS | 2014年 / 107卷

关键词：

Carbapenemases; Detection; Screening; Phenotypic methods; Molecular methods; METALLO-BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE CARBAPENEMASE; RESISTANT ACINETOBACTER-BAUMANNII; DESORPTION IONIZATION-TIME; MEDIATED ISOTHERMAL AMPLIFICATION; MODIFIED HODGE TEST; GRAM-NEGATIVE RODS; PSEUDOMONAS-AERUGINOSA; RAPID DETECTION; CHROMAGAR KPC;

D O I：

10.1016/j.mimet.2014.09.009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes the current state-of-art of carbapenemase detection methods. Identification of carbapenemases is first based on conventional phenotypic tests including antimicrobial susceptibility testing, modified-Hodge test and carbapenemase-inhibitor culture tests. Second, molecular characterization of carbapenemase genes by PCR sequencing is essential. Third, innovative biochemical and spectrometric detection may be applied. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：106 / 118

页数：13

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