Squalenoylation: A generic platform for nanoparticular drug delivery

被引：113
作者：
Desmaele, Didier [1 ]
Gref, Ruxandra [1 ]
Couvreur, Patrick [1 ]
机构：
[1] Univ Paris 11, Fac Pharm, UMR CNRS 8612, F-92296 Chatenay Malabry, France
来源：
JOURNAL OF CONTROLLED RELEASE | 2012年 / 161卷 / 02期
基金：
欧洲研究理事会;
关键词：
Nanoassemblies; Squalenoylation; Nucleosidic analogues; Paclitaxel; Anticancer activity; Antiviral activity; DHA-PACLITAXEL TAXOPREXIN; II OPEN-LABEL; PHASE-I; ANTICANCER NANOMEDICINE; BIOLOGICAL EVALUATION; FATTY-ACID; CELL LINES; GEMCITABINE; SQUALENE; DERIVATIVES;
D O I：
10.1016/j.jconrel.2011.07.038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Squalene is a triterpene widely distributed in nature that is an intermediate in the cholesterol biosynthesis pathway. The remarkable dynamic folded conformation of squalene has been used to chemically conjugate this lipid with various therapeutic molecules to construct nanoassemblies of 100-300 nm. In this review, we discuss the new concept of "squalenoylation" through application to anticancer (i.e. gemcitabine, paclitaxel, cisplatin etc...) or antiviral (ddI, ddC) compounds. In a lego-type approach, it is also possible to construct multifunctional nanoparticles endowed with additional imaging functionalities (i.e. "Nanotheragnostics"). This new nanotechnology platform is expected to have important applications in pharmacology. (c) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：609 / 618
页数：10
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