Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells

被引：7

作者：

Chung, Mi Ja ^{[2
]}

Kim, Jeong-Mi ^{[1
,3
]}

Lee, Sangchul ^{[3
]}

Kim, Taewoo ^{[4
]}

Kim, Daejung ^{[4
]}

Baek, Jongmi ^{[1
]}

Kim, Taehyuk ^{[1
]}

Lee, Jaesung ^{[1
]}

Kim, Kyoungkon ^{[1
]}

Yoon, Jin A. ^{[5
]}

Choe, Myeon ^{[1
,4
]}

机构：

[1] Kangwon Natl Univ, Coll Biomed Sci, Div Biohlth Technol, Chunchon 200701, Gangwon, South Korea

[2] Kangwon Natl Univ, Nutraceut Bio Brain Korea Project Grp 21, Chunchon 200701, South Korea

[3] Borinara Co LTD, Corporate Affiliated Res Inst Acad Ind Inst Coope, Chunchon 200870, South Korea

[4] Kangwon Natl Univ, Well Being Bioprod RIC Ctr, Chunchon 200701, South Korea

[5] Baewha Womens Univ, Dept Food & Nutr, Seoul 110735, South Korea

来源：

NUTRITION RESEARCH AND PRACTICE | 2012年 / 6卷 / 02期

关键词：

Allergic diseases; antioxidant; cytokine; RBL-2H3; cells; Schizandra chinensis Baillon; MAST-CELLS; ASTHMA; ANTIOXIDANT; DERIVATIVES; METABOLISM; ACTIVATION; STOMACH; RELEASE; ACID; MICE;

D O I：

10.4162/nrp.2012.6.2.97

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Schizandra chinensis Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. This study was designed to investigate mechanisms of anti-allergic activity of a Schizandra chinensis Baillon water extract (SCWE) in immunoglobulin E (IgE)-antigen complex-stimulated RBL2H3 cells and to assess whether gastric and intestinal digestion affects the anti-allergic properties of SCWE. Oxidative stress is an important consequence of the allergic inflammatory response. The antioxidant activities of SCWE increased in a concentration-dependent manner. RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific IgE, treated with SCWE, and challenged with the antigen DNP-human serum albumin. SCWE inhibited beta-hexosaminidase release and expression of interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha (TNF-alpha) mRNA and protein in IgE-antigen complex-stimulated RBL2H3 cells. We found that digested SCWE fully maintained its antioxidant activity and anti-allergic activity against the IgE-antigen complex-induced activation of RBL-2H3 cells. SCWE may be useful for preventing allergic diseases, such as asthma. Thus, SCWE could be used as a natural functional ingredient for allergic diseases in the food and/or pharmaceutical industries.

引用

页码：97 / 105

页数：9

共 28 条

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