Drosophila as a genetic model for studying pathogenic human viruses

被引：54

作者：

Hughes, Tamara T. ^{[1
]}

Allen, Amanda L. ^{[1
]}

Bardin, Joseph E. ^{[1
]}

Christian, Megan N. ^{[1
]}

Daimon, Kansei ^{[1
]}

Dozier, Kelsey D. ^{[1
]}

Hansen, Caom L. ^{[1
]}

Holcomb, Lisa M. ^{[1
]}

Ahlander, Joseph ^{[1
]}

机构：

[1] NE State Univ, Dept Nat Sci, Tahlequah, OK 74464 USA

来源：

VIROLOGY | 2012年 / 423卷 / 01期

基金：

美国国家科学基金会;

关键词：

Drosophila; Viruses; GAL4/UAS system; Transgenic expression; Model organism; Human pathogens; ACUTE RESPIRATORY SYNDROME; DEPENDENT IMMUNE-RESPONSES; CORONAVIRUS 3A PROTEIN; RNA INTERFERENCE; MELANOGASTER CELLS; DOWN-REGULATION; SINDBIS VIRUS; DENGUE VIRUS; IN-VIVO; EXPRESSION;

D O I：

10.1016/j.virol.2011.11.016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1 / 5

页数：5

共 59 条

[1] Modeling early Epstein-Barr virus infection in Drosophila melanogaster:: The BZLF1 protein [J].

Adamson, AL ;

Wright, N ;

LaJeunesse, DR .

GENETICS, 2005, 171 (03) :1125-1135

[2] A Drosophila Model for Genetic Analysis of Influenza Viral/Host Interactions [J].

Adamson, Amy L. ;

Chohan, Kultaran ;

Swenson, Jennifer ;

LaJeunesse, Dennis .

GENETICS, 2011, 189 (02) :495-U549

[3] E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila [J].

Asano, M ;

Wharton, RP .

EMBO JOURNAL, 1999, 18 (09) :2435-2448

[4] A Novel System for the Launch of Alphavirus RNA Synthesis Reveals a Role for the Imd Pathway in Arthropod Antiviral Response [J].

Avadhanula, Vasanthi ;

Weasner, Brandon P. ;

Hardy, Gail G. ;

Kumar, Justin P. ;

Hardy, Richard W. .

PLOS PATHOGENS, 2009, 5 (09)

[5]

Battaglia PA, 2001, J CELL SCI, V114, P2787

[6] C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference Response [J].

Brackney, Doug E. ;

Scott, Jaclyn C. ;

Sagawa, Fumihiko ;

Woodward, Jimmy E. ;

Miller, Neil A. ;

Schilkey, Faye D. ;

Mudge, Joann ;

Wilusz, Jeffrey ;

Olson, Ken E. ;

Blair, Carol D. ;

Ebel, Gregory D. .

PLOS NEGLECTED TROPICAL DISEASES, 2010, 4 (10)

[7] A CIS-ACTING REPRESSIVE SEQUENCE THAT OVERLAPS THE REV-RESPONSIVE ELEMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REGULATES NUCLEAR RETENTION OF ENV MESSENGER-RNAS INDEPENDENTLY OF KNOWN SPLICE SIGNALS [J].

BRIGHTY, DW ;

ROSENBERG, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (18) :8314-8318

[8] Neurodegenerative Effects of Recombinant HIV-1 Tat(1-86) are Associated with Inhibition of Microtubule Formation and Oxidative Stress-Related Reductions in Microtubule-Associated Protein-2(a,b) [J].

Butler, Tracy R. ;

Smith, Katherine J. ;

Self, Rachel L. ;

Braden, Brittany B. ;

Prendergast, Mark A. .

NEUROCHEMICAL RESEARCH, 2011, 36 (05) :819-828

[9] COMPARISON OF THE CONSENSUS SEQUENCE FLANKING TRANSLATIONAL START SITES IN DROSOPHILA AND VERTEBRATES [J].

CAVENER, DR .

NUCLEIC ACIDS RESEARCH, 1987, 15 (04) :1353-1361

[10] The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway [J].

Chan, Chak-Ming ;

Ma, Cheuk-Wing ;

Chan, Wood-Yee ;

Chan, Ho Yin Edwin .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007, 459 (02) :197-207

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