The Interplay of Oxidative Stress and ROS Scavenging: Antioxidants as a Therapeutic Potential in Sepsis

被引:64
作者
Kumar, Sanni [1 ]
Saxena, Juhi [2 ]
Srivastava, Vijay Kumar [1 ]
Kaushik, Sanket [1 ]
Singh, Himadri [3 ]
Abo-El-Sooud, Khaled [4 ]
Abdel-Daim, Mohamed M. [5 ,6 ]
Jyoti, Anupam [2 ]
Saluja, Rohit [7 ]
机构
[1] Amity Univ Rajasthan, Amity Inst Biotechnol, NH-11C, Jaipur 303002, Rajasthan, India
[2] Chandigarh Univ, Univ Inst Biotechnol, Dept Biotechnol, Sas Nagar 140413, Punjab, India
[3] All India Inst Med Sci AIIMS, Dept Biochem, Bhopal 462020, Madhya Pradesh, India
[4] Cairo Univ, Fac Vet Med, Pharmacol Dept, Giza 12211, Egypt
[5] Batterjee Med Coll, Dept Pharmaceut Sci, Pharm Program, POB 6231, Jeddah 21442, Saudi Arabia
[6] Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia 41522, Egypt
[7] All India Inst Med Sci AIIMS, Bibinagar 508126, Telangana, India
关键词
sepsis; oxidative stress; ROS; antioxidant; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; SYSTEMIC INFLAMMATORY RESPONSE; VITAMIN-E SUPPLEMENTATION; SUPEROXIDE-DISMUTASE SOD; IMPROVES LIVER-FUNCTION; SEPTIC SHOCK PATIENTS; REACTIVE OXYGEN; ALPHA-TOCOPHEROL; BETA-CAROTENE;
D O I
10.3390/vaccines10101575
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Oxidative stress resulting from the disproportion of oxidants and antioxidants contributes to both physiological and pathological conditions in sepsis. To combat this, the antioxidant defense system comes into the picture, which contributes to limiting the amount of reactive oxygen species (ROS) leading to the reduction of oxidative stress. However, a strong relationship has been found between scavengers of ROS and antioxidants in preclinical in vitro and in vivo models. ROS is widely believed to cause human pathology most specifically in sepsis, where a small increase in ROS levels activates signaling pathways to initiate biological processes. An inclusive understanding of the effects of ROS scavenging in cellular antioxidant signaling is essentially lacking in sepsis. This review compiles the mechanisms of ROS scavenging as well as oxidative damage in sepsis, as well as antioxidants as a potent therapeutic. Direct interaction between ROS and cellular pathways greatly affects sepsis, but such interaction does not provide the explanation behind diverse biological outcomes. Animal models of sepsis and a number of clinical trials with septic patients exploring the efficiency of antioxidants in sepsis are reviewed. In line with this, both enzymatic and non-enzymatic antioxidants were effective, and results from recent studies are promising. The usage of these potent antioxidants in sepsis patients would greatly impact the field of medicine.
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页数:22
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