Therapeutic potential of statins in thyroid proliferative disease

被引：11

作者：

Bifulco, Maurizio ^{[1
]}

机构：

[1] Univ Salerno, Dept Pharmaceut Sci, I-84084 Salerno, Italy

来源：

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM | 2008年 / 4卷 / 05期

关键词：

D O I：

10.1038/ncpendmet0782

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins are traditionally used in patients with hypercholesterolemia and cardiovascular disorders. More recently, however, statins have been shown to exert pleiotropic effects on cell proliferation, survival, and migration, which suggests they could have chemopreventive properties. The author of this Viewpoint proposes that statins might have therapeutic potential in thyroid proliferative disease.

引用

页码：242 / 243

页数：2

共 10 条

[1] Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis [J].

Bifulco, M .

LIFE SCIENCES, 2005, 77 (14) :1740-1749

[2] Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells [J].

Bifulco, M ;

Laezza, C ;

Aloj, SM .

BIOCHIMIE, 1999, 81 (04) :287-290

[3] Reduced thyroid volume and nodularity in dyslipidaemic patients on statin treatment [J].

Cappelli, Carlo ;

Castellano, Maurizio ;

Pirola, Ilenia ;

De Martino, Elvira ;

Gandossi, Elena ;

Delbarba, Andrea ;

Salvi, Andrea ;

Rosei, Enrico Agabiti .

CLINICAL ENDOCRINOLOGY, 2008, 68 (01) :16-21

[4]

FRIEDMAN GD, 2007, PHARMACOEPIDEMIOL DR

[5] v-K-ras leads to preferential farnesylation of p21ras in FRTL-5 cells:: Multiple interference with the isoprenoid pathway [J].

Laezza, C ;

Di Marzo, V ;

Bifulco, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) :13646-13651

[6] HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway [J].

Laezza, Chiara ;

Mazziotti, Gherardo ;

Fiorentino, Laura ;

Gazzerro, Patrizia ;

Portella, Giuseppe ;

Gerbasio, Diego ;

Carella, Carlo ;

Matarese, Giuseppe ;

Bifulco, Maurizio .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2006, 84 (11) :967-973

[7] Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells [J].

Libertini, Silvana ;

Iacuzzo, Irma ;

Ferraro, Angelo ;

Vitale, Mario ;

Bifulco, Maurizio ;

Fusco, Alfredo ;

Portella, Giuseppe .

ENDOCRINOLOGY, 2007, 148 (11) :5186-5194

[8] Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent, CrmA-sensitive, and caspase-3-like protease-dependent mechanism [J].

Vitale, M ;

Di Matola, T ;

Rossi, G ;

Laezza, C ;

Fenzi, G ;

Bifulco, M .

ENDOCRINOLOGY, 1999, 140 (02) :698-704

[9] Lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, induces apoptosis and differentiation in human anaplastic thyroid carcinoma cells [J].

Wang, CY ;

Zhong, WB ;

Chang, TC ;

Lai, SM ;

Tsai, YF .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (07) :3021-3026

[10] Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling [J].

Zhong, WB ;

Liang, YC ;

Wang, CY ;

Chang, TC ;

Lee, WS .

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