Modeling the drugs release from composite materials based on collagen

被引:1
|
作者
Gijiu, Cristiana Luminita [1 ]
Dinculescu, Daniel Dumitru [1 ]
Rau, Ileana [1 ]
Tihan, Gratiela [1 ]
Ghica, Mihaela [2 ]
机构
[1] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Str Polizu 1, Bucharest, Romania
[2] Carol Davila Univ Med & Pharm, Fac Pharm, Bucharest, Romania
关键词
Collagen based materials; drug release modeling; ibuprofen; DELIVERY;
D O I
10.1080/15421406.2017.1361300
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Following the growing interest from year to year in synthesizing composite materials used for drug release, this paper proposes a theoretical investigation in order to contribute to the development of a mathematical model able to describe the process mentioned above. The majority of the models presented in literature are empirical, more or less complex. We propose here a theoretical mathematical model, based on physical phenomena such as diffusion in porous media in unsteady state. The simplifying assumptions of the model concerning the geometry and the morphology of the composite materials will be presented and discussed.
引用
收藏
页码:250 / 254
页数:5
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