Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders

被引：118
作者：
Heinecke, JW
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63130 USA
[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63130 USA
来源：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1999年 / 133卷 / 04期
关键词：
D O I：
10.1016/S0022-2143(99)90061-6
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
[No abstract available]
引用
收藏
页码：321 / 325
页数：5
相关论文
共 32 条
[1]   BIOLOGICAL REACTIVITY OF HYPOCHLOROUS ACID - IMPLICATIONS FOR MICROBICIDAL MECHANISMS OF LEUKOCYTE MYELOPEROXIDASE [J].
ALBRICH, JM ;
MCCARTHY, CA ;
HURST, JK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (01) :210-214
[2]   Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein - A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation [J].
Anderson, MM ;
Hazen, SL ;
Hsu, FF ;
Heinecke, JW .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (03) :424-432
[3]   ROLE OF OXIDATIVE STRESS IN DEVELOPMENT OF COMPLICATIONS IN DIABETES [J].
BAYNES, JW .
DIABETES, 1991, 40 (04) :405-412
[4]   The role of oxidized lipoproteins in atherogenesis [J].
Berliner, JA ;
Heinecke, JW .
FREE RADICAL BIOLOGY AND MEDICINE, 1996, 20 (05) :707-727
[5]   Chronic infections and coronary heart disease: is there a link? [J].
Danesh, J ;
Collins, R ;
Peto, R .
LANCET, 1997, 350 (9075) :430-436
[6]   MYELOPEROXIDASE, A CATALYST FOR LIPOPROTEIN OXIDATION, IS EXPRESSED IN HUMAN ATHEROSCLEROTIC LESIONS [J].
DAUGHERTY, A ;
DUNN, JL ;
RATERI, DL ;
HEINECKE, JW .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :437-444
[7]   OXIDATIVE TYROSYLATION OF HIGH-DENSITY-LIPOPROTEIN BY PEROXIDASE ENHANCES CHOLESTEROL REMOVAL FROM CULTURED FIBROBLASTS AND MACROPHAGE FOAM CELLS [J].
FRANCIS, GA ;
MENDEZ, AJ ;
BIERMAN, EL ;
HEINECKE, JW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6631-6635
[8]   BINDING-SITE ON MACROPHAGES THAT MEDIATES UPTAKE AND DEGRADATION OF ACETYLATED LOW-DENSITY LIPOPROTEIN, PRODUCING MASSIVE CHOLESTEROL DEPOSITION [J].
GOLDSTEIN, JL ;
HO, YK ;
BASU, SK ;
BROWN, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (01) :333-337
[9]  
HARRISON JE, 1976, J BIOL CHEM, V251, P1371
[10]   Human neutrophils employ myeloperoxidase to convert α-amino acids to a battery of reactive aldehydes:: A pathway for aldehyde generation at sites of inflammation [J].
Hazen, SL ;
Hsu, FF ;
d'Avignon, A ;
Heinecke, JW .
BIOCHEMISTRY, 1998, 37 (19) :6864-6873
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