Pattern of MHC class I and immune proteasome expression in Walker 256 tumor during growth and regression in Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis

被引：8

作者：

Zakharova, Liudmila A. ^{[1
]}

Khegai, Igor I. ^{[2
]}

Sharova, Natalia P. ^{[1
]}

Melnikova, Victoria I. ^{[1
]}

Karpova, Yaroslava D. ^{[1
]}

Astakhova, Tatiana M. ^{[1
]}

Popova, Nelly A. ^{[2
]}

Ivanova, Liudmila N. ^{[2
]}

机构：

[1] Russian Acad Sci, NK Koltsov Dev Biol Inst, Moscow 119334, Russia

[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

来源：

CELLULAR IMMUNOLOGY | 2011年 / 271卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

MHC class I; Immune proteasomes; Walker; 256; carcinosarcoma; AVP deficient Brattleboro rats; Tumor regression; DOWN-REGULATION; T-CELLS; ANTIGEN; STRESS; GENE; IMMUNOREACTIVITY; DEGRADATION; MECHANISMS; GENERATION; PATHWAYS;

D O I：

10.1016/j.cellimm.2011.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dynamics of the expression of MHC class I, immune proteasomes and proteasome regulators 195, PA28, total proteasome pool and proteasome chymotrypsin-like activity in Walker 256 tumor after implantation into Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis was studied. The tumor growth and regression in Brattleboro rats were accompanied by changes in the proteasome subunit level unlike the tumor growth in WAG rats with normal expression of arginine-vasopressin gene. In the tumor implanted into Brattleboro rats the immune proteasome level was maximal between days 14 and 17, when the tumor underwent regression. Conversely, the expression of proteasome regulators tended to decrease during this period. Immune proteasomes are known to produce antigen epitopes for MHC class I to be presented to CD8+ T lymphocytes. Enhanced expression of immune proteasomes coincided with the recovery of MHC class I expression, suggesting the efficient presentation of tumor antigens in Brattleboro rats. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：385 / 391

页数：7

共 7 条

[1] Features of the Immune Proteasome Expression in Ascite Zajdela Hepatoma after Implantation into Brattleboro Rats with the Hereditary Defect of Arginine-Vasopressin Synthesis
Mel'nikova, V. I.
Khegai, I. I.
Popova, N. A.
Lifantseva, N. V.
Ivanova, L. N.
Zakharova, L. A.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2014, 40 (06) : 658 - 665
[2] Features of the immune proteasome expression in ascite Zajdela hepatoma after implantation into Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis
V. I. Mel’nikova
I. I. Khegai
N. A. Popova
N. V. Lifantseva
L. N. Ivanova
L. A. Zakharova
Russian Journal of Bioorganic Chemistry, 2014, 40 : 658 - 665
[3] Pattern of proteasome expression in Walker 256 tumor cells after their transplantation into the Brattleboro rats with genetic defect of vasopressin synthesis
N. P. Sharova
V. I. Mel’nikova
I. I. Khegai
Ya. D. Karpova
S. B. Dmitrieva
T. M. Astakhova
M. A. Afanas’eva
N. A. Popova
L. N. Ivanova
L. A. Zakharova
Doklady Biochemistry and Biophysics, 2008, 419 : 93 - 97
[4] Expression of the RT1A molecule of the class I major histocompatibility complex in a walker 256 tumor after transplantation into brattleboro rats with a genetic defect of arginine-vasopressin synthesis
V. I. Mel’nikova
I. I. Khegai
M. A. Afanas’eva
L. N. Ivanova
L. A. Zakharova
Biology Bulletin, 2013, 40 : 103 - 106
[5] Walker 256 tumor growth in rats with hereditary defect of vasopressin synthesis
Khegai, I. I.
Popova, N. A.
Zakharova, L. A.
Ivanova, L. N.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2006, 142 (03) : 344 - 346
[6] Expression of the RT1A molecule of the class I major histocompatibility complex in a walker 256 tumor after transplantation into brattleboro rats with a genetic defect of arginine-vasopressin synthesis
Mel'nikova, V. I.
Khegai, I. I.
Afanas'eva, M. A.
Ivanova, L. N.
Zakharova, L. A.
BIOLOGY BULLETIN, 2013, 40 (01) : 103 - 106
[7] Walker 256 tumor MHC class I expression during the shift from A variant to the immunogenic AR variant
Schanoski, AS
Cavalcanti, TC
Barbosa, C
Campos, L
Viera-Matos, AN
Rettori, O
Guimaraes, F
CANCER LETTERS, 2004, 211 (01) : 119 - 127

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