Ruthenium-based complex nanocarriers for cancer therapy

被引：75

作者：

Mangiapia, Gaetano ^{[1
]}

D'Errico, Gerardino ^{[1
]}

Simeone, Luca ^{[1
]}

Irace, Carlo ^{[2
]}

Radulescu, Aurel ^{[3
]}

Di Pascale, Antonio ^{[2
]}

Colonna, Alfredo ^{[2
]}

Montesarchio, Daniela ^{[1
]}

Paduano, Luigi ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Sci Chim, I-80126 Naples, Italy

[2] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[3] Julich Ctr Neutron Sci, D-85747 Garching, Germany

来源：

BIOMATERIALS | 2012年 / 33卷 / 14期

关键词：

Ruthenium-based complexes; Antineoplastic agents; Nanoaggregates; Anti-proliferative activity; ANGLE NEUTRON-SCATTERING; NAMI-A; GADOLINIUM COMPLEXES; CHEMICAL-STABILITY; CONTRAST AGENTS; TERNARY-SYSTEM; PLATINUM DRUGS; PHASE-I; COEFFICIENTS; CHOLESTEROL;

D O I：

10.1016/j.biomaterials.2012.01.057

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3770 / 3782

页数：13

共 50 条

[31] Ruthenium-based catalysts for aerobic oxidation of alcohols
Advanced Biomedical Engineering Research Unit, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Katsura, Nishikyo-ku, Kyoto
615-8510, Japan
不详
615-8510, Japan
不详
611-0011, Japan
RSC Green Chem., 28 (70-91):
[32] Ruthenium-based catalysts for olefin insertion polymerization
Guan, Zhibin
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
[33] Reactivation of a Ruthenium-Based Olefin Metathesis Catalyst
Tabari, Daniel S.
Tolentino, Daniel R.
Schrodi, Yann
ORGANOMETALLICS, 2013, 32 (01) : 5 - 8
[34] Targeting Glioblastoma: Efficacy of Ruthenium-Based Drugs
Rasin, Puthiyavalappil
Surendran, Sravan Sangeeth
Karthik, K. S.
Haribabu, Jebiti
Sreekanth, Anandaram
CHEMICAL RESEARCH IN TOXICOLOGY, 2024, 37 (09) : 1453 - 1455
[35] In Situ Bioconjugation of a Maleimide-Functionalized Ruthenium-Based Photosensitizer to Albumin for Photodynamic Therapy
Vinck, Robin
Domotor, Orsolya
Karges, Johannes
Jakubaszek, Marta
Seguin, Johanne
Tharaud, Mickael
Guerineau, Vincent
Cariou, Kevin
Mignet, Nathalie
Enyedy, Eva A.
Gasser, Gilles
INORGANIC CHEMISTRY, 2023, 62 (38) : 15510 - 15526
[36] Evaluation of Ruthenium-Based Assemblies as Carriers of Photosensitizers to Treat Rheumatoid Arthritis by Photodynamic Therapy
Gallardo-Villagran, Manuel
Paulus, Lucie
Charissoux, Jean-Louis
Sutour, Sylvain
Vergne-Salle, Pascale
Leger, David Yannick
Liagre, Bertrand
Therrien, Bruno
PHARMACEUTICS, 2021, 13 (12)
[37] Electronic structure of ternary ruthenium-based hydrides
Orgaz, Emilio
Aburto, Andrea
JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (39): : 15586 - 15594
[38] Recent advances in ruthenium-based olefin metathesis
Ogba, O. M.
Warner, N. C.
O'Leary, D. J.
Grubbs, R. H.
CHEMICAL SOCIETY REVIEWS, 2018, 47 (12) : 4510 - 4544
[39] Ruthenium-based chemotherapeutics: are they ready for prime time?
Emmanuel S. Antonarakis
Ashkan Emadi
Cancer Chemotherapy and Pharmacology, 2010, 66 : 1 - 9
[40] Nanocarriers for cancer therapy
Vergaro, Viviana
Zheng, Zhiguo
Zhang, Xingcai
Lvov, Yuri M.
Leporatti, Stefano
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241

← 1 2 3 4 5 →